TY - JOUR
T1 - Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study
AU - Jiao, Li
AU - Stolzenberg-Solomon, Rachael
AU - Zimmerman, Thea Palmer
AU - Duan, Zhigang
AU - Chen, Liang
AU - Kahle, Lisa
AU - Risch, Adam
AU - Subar, Amy F.
AU - Cross, Amanda J.
AU - Hollenbeck, Albert
AU - Vlassara, Helen
AU - Striker, Gary
AU - Sinha, Rashmi
N1 - Publisher Copyright:
© 2015 American Society for Nutrition
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Advanced glycation end products (AGEs) are a heterogeneous group of compounds present in uncooked foods as well as in foods cooked at high temperatures. AGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes. Dietary AGEs are an important contributor to the AGE pool in the body. N∈-(carboxymethyl)lysine (CML) AGE is one of the major biologically and chemically well-characterized AGE markers. The consumption of red meat, which is CML-AGE rich, has been positively associated with pancreatic cancer in men. Objectives: With the use of a published food CML-AGE database, we estimated the consumption of CML AGE in the prospective NIH-AARP Diet and Health Study and evaluated the association between CML-AGE consumption and pancreatic cancer and the mediating effect of CML AGE on the association between red meat consumption and pancreatic cancer. Design: Multivariate Cox proportional hazard regression models were used to estimate HRs and 95% CIs for pancreatic cancer. Results: During an average of 10.5 y of follow-up, we identified 2193 pancreatic cancer cases (1407 men and 786 women) from 528,251 subjects. With the comparison of subjects in the fifth and the first quintiles of CML-AGE consumption, we observed increased pancreatic cancer risk in men (HR: 1.43; 95% CI: 1.06, 1.93, P-trend = 0.003) but not women (HR: 1.14; 95% CI: 0.76, 1.72, P-trend = 0.42). Men in the highest quintile of red meat consumption had higher risk of pancreatic cancer (HR: 1.35; 95% CI: 1.07, 1.70), which attenuated after adjustment for CML-AGE consumption (HR: 1.20; 95% CI: 0.95, 1.53). Conclusion: Dietary CML-AGE consumption was associated with modestly increased risk of pancreatic cancer in men and may partially explain the positive association between red meat and pancreatic cancer. The NIH-AARP Diet and Health Study was registered at clinicaltrials.gov as NCT00340015.
AB - Background: Advanced glycation end products (AGEs) are a heterogeneous group of compounds present in uncooked foods as well as in foods cooked at high temperatures. AGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes. Dietary AGEs are an important contributor to the AGE pool in the body. N∈-(carboxymethyl)lysine (CML) AGE is one of the major biologically and chemically well-characterized AGE markers. The consumption of red meat, which is CML-AGE rich, has been positively associated with pancreatic cancer in men. Objectives: With the use of a published food CML-AGE database, we estimated the consumption of CML AGE in the prospective NIH-AARP Diet and Health Study and evaluated the association between CML-AGE consumption and pancreatic cancer and the mediating effect of CML AGE on the association between red meat consumption and pancreatic cancer. Design: Multivariate Cox proportional hazard regression models were used to estimate HRs and 95% CIs for pancreatic cancer. Results: During an average of 10.5 y of follow-up, we identified 2193 pancreatic cancer cases (1407 men and 786 women) from 528,251 subjects. With the comparison of subjects in the fifth and the first quintiles of CML-AGE consumption, we observed increased pancreatic cancer risk in men (HR: 1.43; 95% CI: 1.06, 1.93, P-trend = 0.003) but not women (HR: 1.14; 95% CI: 0.76, 1.72, P-trend = 0.42). Men in the highest quintile of red meat consumption had higher risk of pancreatic cancer (HR: 1.35; 95% CI: 1.07, 1.70), which attenuated after adjustment for CML-AGE consumption (HR: 1.20; 95% CI: 0.95, 1.53). Conclusion: Dietary CML-AGE consumption was associated with modestly increased risk of pancreatic cancer in men and may partially explain the positive association between red meat and pancreatic cancer. The NIH-AARP Diet and Health Study was registered at clinicaltrials.gov as NCT00340015.
KW - Advanced glycation end products
KW - Diet
KW - Inflammation
KW - Pancreatic cancer
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=84919664382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919664382&partnerID=8YFLogxK
U2 - 10.3945/ajcn.114.098061
DO - 10.3945/ajcn.114.098061
M3 - Article
C2 - 25527756
AN - SCOPUS:84919664382
SN - 0002-9165
VL - 101
SP - 126
EP - 134
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -