TY - JOUR
T1 - Dietary intake of selected fatty acids, cholesterol and carotenoids and estrogen receptor status in premenopausal breast cancer patients
AU - Jakovljevic, Jelena
AU - Touillaud, Marina S.
AU - Bondy, Melissa L.
AU - Singletary, S. Eva
AU - Pillow, Patricia C.
AU - Chang, Shine
N1 - Funding Information:
We would like to thank Julie Alderfer, R.N., of the Department of Surgical Oncology, and Elaine S. Petrulis, M.P.H., and Tonya Khan, M.P.H., of the Department of Epidemiology at The University of Texas M. D. Anderson Cancer Center for their help in abstracting and collecting data used in these analyses. This work was supported by grants from the National Cancer Institute, awarded to The University of Texas M. D. Anderson Cancer Center Education Program in Cancer Prevention Education – Student Research Experiences grant (CA# 56452), to Dr Melissa L. Bondy (CA# 70264) and to Dr Donghui Li (CA# 70264). This research was also supported by funds from The M. D. Anderson Breast Cancer Program and a grant from the US Department of Defense Congressionally Directed Medical Research Program in Breast Cancer (S/C DAMD 179616292, to Dr S. Eva Singletary). Dr Shine Chang was supported in part by a Clinical Research Training Grant for Junior Faculty from the American Cancer Society.
PY - 2002/9
Y1 - 2002/9
N2 - Although a wealth of research has focused on the influence of diet on breast cancer risk, the relationships between dietary factors and tumor characteristics of breast cancer, like estrogen receptor (ER) status, are not well characterized. In a case-case study, we evaluated self-reported dietary intake for five individual carotenoids, selected fatty acids, and cholesterol 1 year before diagnosis in 34 premenopausal breast cancer patients with ER-negative tumors and 86 premenopausal breast cancer patients with ER-positive tumors from The University of Texas M. D. Anderson Cancer Center. In multivariate logistic regression analysis adjusted for age, body mass index, and ethnicity, high intakes of linoleic acid were associated with more than a threefold greater risk of ER-negative disease than ER-positive disease (odds ratio (OR) = 3.48, 95% confidence interval (CT) = 1.42-8.54), whereas high cholesterol intake was associated with lower risk of ER-negative disease (OR = 0.35, 95% CI = 0.14-0.92). In a model evaluating carotenoids, selected fatty acids, and cholesterol together, the association with high intake of linoleic acid remained statistically significant (OR = 3.96, 95% CI = 1.53-10.25), while those for high intake of cholesterol (OR = 0.38, 95% CI = 0.14-1.03) and low intake of cryptoxanthin (OR = 0.43, 95% CI = 0.17-1.06) were of marginal significance. While no striking associations were observed for the intakes of total carotenoids, selected fatty acids, and cholesterol, our analysis revealed an association for the consumption of a specific fatty acid (i.e., linoleic acid), suggesting dietary influence of this factor on ER status in premenopausal breast cancer patients. However, larger studies are needed to clarify the role of micronutrients in ER status in breast cancer.
AB - Although a wealth of research has focused on the influence of diet on breast cancer risk, the relationships between dietary factors and tumor characteristics of breast cancer, like estrogen receptor (ER) status, are not well characterized. In a case-case study, we evaluated self-reported dietary intake for five individual carotenoids, selected fatty acids, and cholesterol 1 year before diagnosis in 34 premenopausal breast cancer patients with ER-negative tumors and 86 premenopausal breast cancer patients with ER-positive tumors from The University of Texas M. D. Anderson Cancer Center. In multivariate logistic regression analysis adjusted for age, body mass index, and ethnicity, high intakes of linoleic acid were associated with more than a threefold greater risk of ER-negative disease than ER-positive disease (odds ratio (OR) = 3.48, 95% confidence interval (CT) = 1.42-8.54), whereas high cholesterol intake was associated with lower risk of ER-negative disease (OR = 0.35, 95% CI = 0.14-0.92). In a model evaluating carotenoids, selected fatty acids, and cholesterol together, the association with high intake of linoleic acid remained statistically significant (OR = 3.96, 95% CI = 1.53-10.25), while those for high intake of cholesterol (OR = 0.38, 95% CI = 0.14-1.03) and low intake of cryptoxanthin (OR = 0.43, 95% CI = 0.17-1.06) were of marginal significance. While no striking associations were observed for the intakes of total carotenoids, selected fatty acids, and cholesterol, our analysis revealed an association for the consumption of a specific fatty acid (i.e., linoleic acid), suggesting dietary influence of this factor on ER status in premenopausal breast cancer patients. However, larger studies are needed to clarify the role of micronutrients in ER status in breast cancer.
KW - Breast cancer
KW - Carotenoids
KW - Diet
KW - Estrogen receptor status
KW - Estrogen receptors
KW - Fat
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U2 - 10.1023/A:1016588629495
DO - 10.1023/A:1016588629495
M3 - Article
C2 - 12500930
AN - SCOPUS:0036707704
SN - 0167-6806
VL - 75
SP - 5
EP - 14
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 1
ER -