Abstract
To distinguish keratoacanthomas from squamous cell carcinomas remains a diagnostic challenge in dermatopathology. Several immunohistochemical and cytogenetic markers have been evaluated; however, so far there has been no unequivocal evidence supporting practical application of any of these markers. Recent studies have evaluated the composition of tumor-associated immune infiltrate, in particular the number and distribution of CD123-positive plasmacytoid dendritic cells in making this distinction; but these cells also do not appear to be a consistent biomarker in distinguishing keratoacanthoma from squamous cell carcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 418-420 |
| Number of pages | 3 |
| Journal | Journal of cutaneous pathology |
| Volume | 47 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2020 |
Keywords
- CD123
- keratoacanthoma
- plasmacytoid dendritic cells
- squamous cell carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology