TY - JOUR
T1 - Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
T2 - Clinicopathologic features of 12 cases
AU - Lin, Pei
AU - Mansoor, Adnan
AU - Bueso-Ramos, Carlos
AU - Hao, Suyang
AU - Lai, Raymond
AU - Medeiros, L. Jeffrey
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Of 92 patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) treated at our institution, diffuse large B-cell lymphoma (DLBCL) also developed in 12 (13%). In 10 patients, DLBCL developed 12 to 128 months (median, 44 months) after the diagnosis of LPL/WM. Two patients had LPL/WM and DLBCL simultaneously. Clinicopathologic features at diagnosis of LPL/WM did not predict the risk of DLBCL. Onset of DLBCL was characterized by worsening constitutional symptoms, profound cytopenias, extramedullary disease, and organomegaly. Immunoglobulin light chain expression was identical in both LPL/WM and DLBCL. In situ hybridization for Epstein-Barr virus (EBV) in 8 cases of DLBCL was negative. Of 11 patients with clinical follow-up information available, 8 (73%) died within 10 months of diagnosis of DLBCL, DLBCL, most likely as a result of histologic transformation, occurs in a subset of patients with LPL/WM and is associated with aggressive clinical course and poor outcome. EBV is unlikely to be involved in transformation.
AB - Of 92 patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) treated at our institution, diffuse large B-cell lymphoma (DLBCL) also developed in 12 (13%). In 10 patients, DLBCL developed 12 to 128 months (median, 44 months) after the diagnosis of LPL/WM. Two patients had LPL/WM and DLBCL simultaneously. Clinicopathologic features at diagnosis of LPL/WM did not predict the risk of DLBCL. Onset of DLBCL was characterized by worsening constitutional symptoms, profound cytopenias, extramedullary disease, and organomegaly. Immunoglobulin light chain expression was identical in both LPL/WM and DLBCL. In situ hybridization for Epstein-Barr virus (EBV) in 8 cases of DLBCL was negative. Of 11 patients with clinical follow-up information available, 8 (73%) died within 10 months of diagnosis of DLBCL, DLBCL, most likely as a result of histologic transformation, occurs in a subset of patients with LPL/WM and is associated with aggressive clinical course and poor outcome. EBV is unlikely to be involved in transformation.
KW - Large cell lymphoma
KW - Lymphoplasmacytic lymphoma
KW - Waldenström macroglobulinemia
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UR - http://www.scopus.com/inward/citedby.url?scp=85047686907&partnerID=8YFLogxK
U2 - 10.1309/R01VXG46MFCDVNHL
DO - 10.1309/R01VXG46MFCDVNHL
M3 - Article
C2 - 12931555
AN - SCOPUS:85047686907
SN - 0002-9173
VL - 120
SP - 246
EP - 253
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 2
ER -