TY - JOUR
T1 - Direct Nerve Implantation Vs. Nerve-Muscle Pedicle
T2 - A Comparative Study of Reinnervation in the Rabbit
AU - Broniatowski, Michael
AU - Ilyes, Laszlo A.
AU - Sorensen, Kelly
AU - Rosenthal, David I.
AU - Nose, Yukihiko
AU - Maniglia, Anthony J.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1989/2
Y1 - 1989/2
N2 - To determine the optimal method for reinnervation of the paralyzed head and neck musculature, we compared direct muscular nerve implants (DNI) with nerve-muscle pedicles (NMP) in rabbits. In 25 anesthetized animals, one ansa hypoglossi nerve was cut. Five animals sensed as controls and two groups of 10 each received cross-over DNIs or NMP from one sternothyroid to the contralateral sternohyoid muscle. The transplanted nerves of animals that survived long enough for neurotization to occur (8 DNIs, 5 NMPs) were stimulated with 3 to 10 mA. 0.05 msec pulse trains to obtain force curves from corresponding straps. Fiber diameters and areas were calculated on muscles harvested before the animals were killed. There was a nonsignificant trend toward stronger contraction in the NMP group, but NMP fibers were significantly larger than those in DNI and control groups (p < 0.001).
AB - To determine the optimal method for reinnervation of the paralyzed head and neck musculature, we compared direct muscular nerve implants (DNI) with nerve-muscle pedicles (NMP) in rabbits. In 25 anesthetized animals, one ansa hypoglossi nerve was cut. Five animals sensed as controls and two groups of 10 each received cross-over DNIs or NMP from one sternothyroid to the contralateral sternohyoid muscle. The transplanted nerves of animals that survived long enough for neurotization to occur (8 DNIs, 5 NMPs) were stimulated with 3 to 10 mA. 0.05 msec pulse trains to obtain force curves from corresponding straps. Fiber diameters and areas were calculated on muscles harvested before the animals were killed. There was a nonsignificant trend toward stronger contraction in the NMP group, but NMP fibers were significantly larger than those in DNI and control groups (p < 0.001).
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U2 - 10.1177/019459988910000208
DO - 10.1177/019459988910000208
M3 - Article
C2 - 2495508
AN - SCOPUS:0024596926
SN - 0194-5998
VL - 100
SP - 126
EP - 133
JO - Otolaryngology–Head and Neck Surgery
JF - Otolaryngology–Head and Neck Surgery
IS - 2
ER -