Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus

Sheng Xiong Huang; Emily Powell; Scott R. Rajski; Li Xing Zhao; Cheng Lin Jiang; Yanwen Duan; Wei Xu; Ben Shen

doi:10.1021/ol1013526

Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus

Sheng Xiong Huang, Emily Powell, Scott R. Rajski, Li Xing Zhao, Cheng Lin Jiang, Yanwen Duan, Wei Xu, Ben Shen

Cancer Biology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

(Equation Presented). Estrogen receptor ERα and ERβ heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERα/β heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.

Original language	English (US)
Pages (from-to)	3525-3527
Number of pages	3
Journal	Organic Letters
Volume	12
Issue number	15
DOIs	https://doi.org/10.1021/ol1013526
State	Published - Aug 6 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus",

abstract = "(Equation Presented). Estrogen receptor ERα and ERβ heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERα/β heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.",

author = "Huang, {Sheng Xiong} and Emily Powell and Rajski, {Scott R.} and Zhao, {Li Xing} and Jiang, {Cheng Lin} and Yanwen Duan and Wei Xu and Ben Shen",

year = "2010",

month = aug,

day = "6",

doi = "10.1021/ol1013526",

language = "English (US)",

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T1 - Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus

AU - Huang, Sheng Xiong

AU - Powell, Emily

AU - Rajski, Scott R.

AU - Zhao, Li Xing

AU - Jiang, Cheng Lin

AU - Duan, Yanwen

AU - Xu, Wei

AU - Shen, Ben

PY - 2010/8/6

Y1 - 2010/8/6

N2 - (Equation Presented). Estrogen receptor ERα and ERβ heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERα/β heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.

AB - (Equation Presented). Estrogen receptor ERα and ERβ heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ERα/β heterodimerization is reported. Total synthesis of 1 has allowed us to determine its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function.

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Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from actinopolymorpha rutilus

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