Abstract
Buzaianu and Chen apply strong curtailment to modify the two-stage select-and-test clinical trial design proposed by Thall et al. (1988). The modification reduces the expected sample size while maintaining overall power but requires continuous monitoring in stage 1. I will review the history of this type of design and discuss practical issues related to the use of strong curtailment that arise in trial conduct.
Original language | English (US) |
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Pages (from-to) | 41-43 |
Number of pages | 3 |
Journal | Sequential Analysis |
Volume | 28 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2009 |
Keywords
- Clinical trials
- Generalized power
- Phase II-III design
ASJC Scopus subject areas
- Statistics and Probability
- Modeling and Simulation