Distinct imaging characteristics of different metastases from primary prostate adenocarcinoma and rectal carcinoid tumor on 18F-Fluciclovine and 68Ga-DOTATATE PET/CT

Andrew John Bosserman; Dong Dai; Yang Lu

doi:10.1097/RLU.0000000000002358

Distinct imaging characteristics of different metastases from primary prostate adenocarcinoma and rectal carcinoid tumor on ¹⁸F-Fluciclovine and ⁶⁸Ga-DOTATATE PET/CT

Andrew John Bosserman, Dong Dai, Yang Lu

Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On ¹⁸F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. On further ⁶⁸Ga-DOTATATE PET/CT, the perirectal lymph node revealed intense DOTATATE avidity, whereas the 2 retroperitoneal lymph nodes only with similar to background DOTATATE avidity. Biopsy of the perirectal lymph node confirmed metastasis from neuroendocrine tumor. The distinct imaging characteristics of metastases from different primary malignancies correlated with their underlying different pathology.

Original language	English (US)
Pages (from-to)	83-84
Number of pages	2
Journal	Clinical nuclear medicine
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/RLU.0000000000002358
State	Published - Jan 1 2019

Keywords

DOTATATE
PET/CT
carcinoid
fluciclovine
neuroendocrine tumor
prostate cancer

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000002358

Cite this

@article{cf6f9bac60ab46858789570979d09115,

title = "Distinct imaging characteristics of different metastases from primary prostate adenocarcinoma and rectal carcinoid tumor on 18F-Fluciclovine and 68Ga-DOTATATE PET/CT",

abstract = "A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On 18F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. On further 68Ga-DOTATATE PET/CT, the perirectal lymph node revealed intense DOTATATE avidity, whereas the 2 retroperitoneal lymph nodes only with similar to background DOTATATE avidity. Biopsy of the perirectal lymph node confirmed metastasis from neuroendocrine tumor. The distinct imaging characteristics of metastases from different primary malignancies correlated with their underlying different pathology.",

keywords = "DOTATATE, PET/CT, carcinoid, fluciclovine, neuroendocrine tumor, prostate cancer",

author = "Bosserman, {Andrew John} and Dong Dai and Yang Lu",

year = "2019",

month = jan,

day = "1",

doi = "10.1097/RLU.0000000000002358",

language = "English (US)",

volume = "44",

pages = "83--84",

journal = "Clinical nuclear medicine",

issn = "0363-9762",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Distinct imaging characteristics of different metastases from primary prostate adenocarcinoma and rectal carcinoid tumor on 18F-Fluciclovine and 68Ga-DOTATATE PET/CT

AU - Bosserman, Andrew John

AU - Dai, Dong

AU - Lu, Yang

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On 18F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. On further 68Ga-DOTATATE PET/CT, the perirectal lymph node revealed intense DOTATATE avidity, whereas the 2 retroperitoneal lymph nodes only with similar to background DOTATATE avidity. Biopsy of the perirectal lymph node confirmed metastasis from neuroendocrine tumor. The distinct imaging characteristics of metastases from different primary malignancies correlated with their underlying different pathology.

AB - A 71-year-old man with history of prostate cancer is evaluated for rising prostate-specific antigen. The patient also has a history of rectal well-differentiated neuroendocrine tumor. On 18F-fluciclovine PET/CT, 2 retroperitoneal lymph nodes exhibited intense fluciclovine avidity, whereas one enlarged perirectal lymph node only showed background uptake. On further 68Ga-DOTATATE PET/CT, the perirectal lymph node revealed intense DOTATATE avidity, whereas the 2 retroperitoneal lymph nodes only with similar to background DOTATATE avidity. Biopsy of the perirectal lymph node confirmed metastasis from neuroendocrine tumor. The distinct imaging characteristics of metastases from different primary malignancies correlated with their underlying different pathology.

KW - DOTATATE

KW - PET/CT

KW - carcinoid

KW - fluciclovine

KW - neuroendocrine tumor

KW - prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85058595092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058595092&partnerID=8YFLogxK

U2 - 10.1097/RLU.0000000000002358

DO - 10.1097/RLU.0000000000002358

M3 - Article

C2 - 30371597

AN - SCOPUS:85058595092

SN - 0363-9762

VL - 44

SP - 83

EP - 84

JO - Clinical nuclear medicine

JF - Clinical nuclear medicine

IS - 1

ER -