TY - JOUR
T1 - Distinctive RNA expression profiles in blood associated with alzheimer disease after accounting for white matter hyperintensities
AU - Bai, Zhouxian
AU - Stamova, Boryana
AU - Xu, Huichun
AU - Ander, Bradley P.
AU - Wang, Jiajia
AU - Jickling, Glen C.
AU - Zhan, Xinhua
AU - Liu, Dazhi
AU - Han, Guangchun
AU - Jin, Lee Way
AU - Decarli, Charles
AU - Lei, Hongxing
AU - Sharp, Frank R.
PY - 2014
Y1 - 2014
N2 - BACKGROUND:: Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. METHODS:: RNA from whole blood was processed on whole-genome microarrays. RESULTS:: A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2. CONCLUSIONS:: RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.
AB - BACKGROUND:: Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. METHODS:: RNA from whole blood was processed on whole-genome microarrays. RESULTS:: A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGFβ1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2. CONCLUSIONS:: RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.
KW - Alzheimer disease
KW - blood
KW - brain
KW - RNA
KW - white matter hyperintensities
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U2 - 10.1097/WAD.0000000000000022
DO - 10.1097/WAD.0000000000000022
M3 - Article
C2 - 24731980
AN - SCOPUS:84907140945
SN - 0893-0341
VL - 28
SP - 226
EP - 233
JO - Alzheimer Disease and Associated Disorders
JF - Alzheimer Disease and Associated Disorders
IS - 3
ER -