Disulfidptosis: disulfide stress–induced cell death

Xiaoguang Liu; Li Zhuang; Boyi Gan

doi:10.1016/j.tcb.2023.07.009

Disulfidptosis: disulfide stress–induced cell death

Xiaoguang Liu, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress–induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.

Original language	English (US)
Pages (from-to)	327-337
Number of pages	11
Journal	Trends in Cell Biology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.tcb.2023.07.009
State	Published - Apr 2024

Keywords

cystine
disulfide stress
disulfidptosis
ferroptosis
SLC7A11
xCT

ASJC Scopus subject areas

Cell Biology

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10.1016/j.tcb.2023.07.009

Cite this

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title = "Disulfidptosis: disulfide stress–induced cell death",

abstract = "The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress–induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.",

keywords = "cystine, disulfide stress, disulfidptosis, ferroptosis, SLC7A11, xCT",

author = "Xiaoguang Liu and Li Zhuang and Boyi Gan",

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T1 - Disulfidptosis

T2 - disulfide stress–induced cell death

AU - Liu, Xiaoguang

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2024/4

Y1 - 2024/4

N2 - The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress–induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.

AB - The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress–induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.

KW - cystine

KW - disulfide stress

KW - disulfidptosis

KW - ferroptosis

KW - SLC7A11

KW - xCT

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Disulfidptosis: disulfide stress–induced cell death

Abstract

Keywords

ASJC Scopus subject areas

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