Abstract
DNA alkylation damage can pose a serious threat to the genetic integrity and cellular survival. To combat this damage, cells employ incredibly vast and elegant repair mechanisms, including excision of damaged nucleotides from DNA, direct removal of the lesion without further modification of the nucleotide or DNA, and a bridging protein that connects DNA repair pathways. The existence of these extensive and creative mechanisms for cellular protection emphasizes the importance of DNA alkyl lesion repair. Here we discuss common causes, types, effects, and repair mechanisms for DNA alkylation damage within cells.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Biological Chemistry |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 9-15 |
| Number of pages | 7 |
| ISBN (Electronic) | 9780123786319 |
| ISBN (Print) | 9780123786302 |
| DOIs | |
| State | Published - Feb 15 2013 |
| Externally published | Yes |
Keywords
- AAG
- AGT
- ATL
- Ada
- AlkA
- AlkB
- Alkyltransferase-like
- Base excision repair
- Base excision repair glycosylase
- DNA alkylation damage
- DNA repair
- Direct damage reversal
- Genome stability
- O-alkylguanine-DNA alkyltransferase
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology