@inbook{a0549120597b4511993bf04fa1465dad,
title = "DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes",
abstract = "Cells have evolved distinct mechanisms for both preventing and removing mutagenic and lethal DNA damage. Structural and biochemical characterization of key enzymes that function in DNA repair pathways are illuminating the biological and chemical mechanisms that govern initial lesion detection, recognition, and excision repair of damaged DNA. These results are beginning to reveal a higher level of DNA repair coordination that ensures the faithful repair of damaged DNA. Enzyme-induced DNA distortions allow for the specific recognition of distinct extrahelical lesions, as well as tight binding to cleaved products, which has implications for the ordered transfer of unstable DNA repair intermediates between enzymes during base excision repair.",
author = "Hosfield, {David J.} and Daniels, {Douglas S.} and Mol, {Clifford D.} and Putnam, {Christopher D.} and Parikh, {Sudip S.} and Tainer, {John A.}",
note = "Funding Information: This work could not have been possible without the patient and expert collaboration with the laboratories of R. P. Cunningham at the State University of New York at Albany; S. Mitra and R. S. Lloyd at the Scaly Center for Molecular Science, University of Texas Medical Branch (UTMB) in Galveston, Texas; B. Shen at the City of Hope National Medical Center and Beckman Research Institute; A. E. Pegg at the Pennsylvania State University College of Medicine; H. E. Krokan and G. Slupphaug at the Norwegian University of Science and Technology; and G. M. Blackburn at the University of Sheffield. We thank the staff and facilities at the Cornell High Energy Synchrotron Source (CHESS), the Stanford Synchrotron Radiation Laboratory (SSRL), the Advanced Light Source (ALS), and the Advanced Photon Source (APS), which are supported by the National Science Foundation and Department of Energy. Work on DNA repair in the Tainer and Cunningham laboratories is supported by the National Institutes of Health grant GM46312, while work in the Tainer and Shen laboratories is supported by the National Institutes of Health grant CA57348. In addition, work on DNA repair is supported by a Special Fellowship (to C.D.M) from the Leukemia and Lymphoma Society (formerly the Leukemia Society of America), The Skaggs Institute for Chemical Biology( D.J.H., S.S.P.), and graduate research fellowships from the Howard Hughes Medical Institute (C.D.P.) and the National Science Foundation (D.S.D., S.S.P.).",
year = "2001",
doi = "10.1016/s0079-6603(01)68110-8",
language = "English (US)",
isbn = "0125400683",
series = "Progress in Nucleic Acid Research and Molecular Biology",
publisher = "Academic Press Inc.",
pages = "315--347",
booktitle = "Base Excesion Repair",
}