DNA double-strand break repair from head to tail

Karl Peter Hopfner; Christopher D. Putnam; John A. Tainer

doi:10.1016/S0959-440X(02)00297-X

DNA double-strand break repair from head to tail

Karl Peter Hopfner, Christopher D. Putnam, John A. Tainer

Research output: Contribution to journal › Review article › peer-review

120 Scopus citations

Abstract

DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

Original language	English (US)
Pages (from-to)	115-122
Number of pages	8
Journal	Current Opinion in Structural Biology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0959-440X(02)00297-X
State	Published - Feb 1 2002
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(02)00297-X

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AU - Tainer, John A.

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N2 - DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

AB - DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

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DNA double-strand break repair from head to tail

Abstract

ASJC Scopus subject areas

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