DNA mismatch repair: The hands of a genome guardian

Karl Peter Hopfner; John A. Tainer

doi:10.1016/S0969-2126(00)00545-1

DNA mismatch repair: The hands of a genome guardian

Karl Peter Hopfner, John A. Tainer

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

Original language	English (US)
Article number	44
Pages (from-to)	R237-R241
Journal	Structure
Volume	8
Issue number	12
DOIs	https://doi.org/10.1016/S0969-2126(00)00545-1
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/S0969-2126(00)00545-1

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title = "DNA mismatch repair: The hands of a genome guardian",

abstract = "DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.",

author = "Hopfner, {Karl Peter} and Tainer, {John A.}",

note = "Funding Information: We thank Susan Tsutakawa, Tom Kunkel and Karin Drotschmann for helpful discussions and comments on the manuscript. KPH is supported by a fellowship from the Studienstiftung des deutschen Volkes and by the Skaggs Institute for Chemical Biology. JAT effort on ABC-ATPases is supported in part by a Laboratory Directed Research and Development grant from the Lawrence Berkeley National Laboratory.",

year = "2000",

doi = "10.1016/S0969-2126(00)00545-1",

language = "English (US)",

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pages = "R237--R241",

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T1 - DNA mismatch repair

T2 - The hands of a genome guardian

AU - Hopfner, Karl Peter

AU - Tainer, John A.

N1 - Funding Information: We thank Susan Tsutakawa, Tom Kunkel and Karin Drotschmann for helpful discussions and comments on the manuscript. KPH is supported by a fellowship from the Studienstiftung des deutschen Volkes and by the Skaggs Institute for Chemical Biology. JAT effort on ABC-ATPases is supported in part by a Laboratory Directed Research and Development grant from the Lawrence Berkeley National Laboratory.

PY - 2000

Y1 - 2000

N2 - DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

AB - DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

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U2 - 10.1016/S0969-2126(00)00545-1

DO - 10.1016/S0969-2126(00)00545-1

M3 - Review article

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AN - SCOPUS:0034483133

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VL - 8

SP - R237-R241

JO - Structure

JF - Structure

IS - 12

M1 - 44

ER -

DNA mismatch repair: The hands of a genome guardian

Abstract

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