Abstract
Modulation of chromatin is essential to nuclear processes that utilize DNA, such as transcription, replication, and repair. For example, transcription is assisted by histone post-translational modifications, as well as chromatin-remodeling complexes, which alter the structure of chromatin. Furthermore, recent advancements in the fields of DNA repair and chromatin reveal that both histone modifications and chromatin-remodeling complexes are essential for the repair of DNA lesions. In particular, chromatin-modifying complexes, such as the INO80 chromatin-remodeling complex and the Tip60 histone acetyltransferase complex, associate with the DNA damage-induced phosphorylated H2AX, which is often referred to as γ-H2AX. In S. cerevisiae, the association of INO80 with γ-H2AX is required for the recruitment of INO80 to sites of DNA double-strand breaks. Additionally, in Drosophila, Tip60 exchanges γ-H2AX for unmodified H2A in regions of DNA damage. This report reviews recent studies that emphasize the intimate relationship between evolutionarily-conserved chromatin-modifying complexes and histone post-translational modifications in the repair of DNA damage.
Original language | English (US) |
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Pages (from-to) | 513-512 |
Number of pages | 2 |
Journal | Cell Cycle |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2005 |
Keywords
- Chromatin
- Chromatin-remodeling complex
- DNA repair
- Histone modification
- INO80
- Tip60
- γ-H2AX
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology