TY - JOUR
T1 - Do lymphocytes contain chromosomal lesions that are also stable markers in cancer cells? Lymphocyte and tumor cell karyotyping in a melanoma patient
AU - Ghayee, Hans K.
AU - Dinney, Colin P.
AU - Pathak, Sen
N1 - Copyright:
Copyright 2005 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1997
Y1 - 1997
N2 - The initiation and metastatic progression of human cancers are genetically controlled. We therefore sought to identify specific chromosomal changes associated with the development of a melanoma and its metastasis to the bladder in a 57-year-old Caucasian man by analyzing his lymphocytes and metastatic melanoma cells. Approximately 4% of the patient's PHA-stimulated lymphocytes showed constitutional abnormalities of chromosomes 1, 2, 3, 4, 7, 9, 10, 12, 14 and 19. On the other hand, his melanoma cells showed clonal markers involving chromosomes 2, 4, 5, 6, 7, 9, 10, 14, 16, 17 and 20 plus many more. Our results indicate that both primary chromosome abnormalities and some of the secondary cytogenetic defects of melanoma cells can be identified in lymphocyte cultures and that such abnormalities may be possible markers for early diagnosis and treatment.
AB - The initiation and metastatic progression of human cancers are genetically controlled. We therefore sought to identify specific chromosomal changes associated with the development of a melanoma and its metastasis to the bladder in a 57-year-old Caucasian man by analyzing his lymphocytes and metastatic melanoma cells. Approximately 4% of the patient's PHA-stimulated lymphocytes showed constitutional abnormalities of chromosomes 1, 2, 3, 4, 7, 9, 10, 12, 14 and 19. On the other hand, his melanoma cells showed clonal markers involving chromosomes 2, 4, 5, 6, 7, 9, 10, 14, 16, 17 and 20 plus many more. Our results indicate that both primary chromosome abnormalities and some of the secondary cytogenetic defects of melanoma cells can be identified in lymphocyte cultures and that such abnormalities may be possible markers for early diagnosis and treatment.
KW - Chromosome abnormalities
KW - Diagnosis
KW - Marker chromosomes
KW - Melanoma cells
KW - Metastasis
KW - Peripheral blood lymphocyte
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M3 - Article
AN - SCOPUS:0030961193
SN - 1019-6439
VL - 11
SP - 681
EP - 684
JO - International journal of oncology
JF - International journal of oncology
IS - 4
ER -