Abstract
Background Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question. Methods CONKO-001 pts with an overall survival ≥5 years were compared to those who survived <5 years. Central re-evaluation of primary histology was performed. Univariate analysis with the χ2-test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS. Results Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival ≥5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS. Conclusion Long-term survival can be achieved in adenocarcinoma of the pancreas. J. Surg. Oncol. 2013; 108:398-402.
Original language | English (US) |
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Pages (from-to) | 398-402 |
Number of pages | 5 |
Journal | Journal of surgical oncology |
Volume | 108 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2013 |
Keywords
- adjuvant therapy
- gemcitabine
- rate of cure
ASJC Scopus subject areas
- Surgery
- Oncology