Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

Nemai Saha; Haiwen Wang; Shengyi Zhang; Yongliang Du; Daqian Zhu; Yumin Hu; Peng Huang; Shijun Wen

doi:10.1021/acs.orglett.7b03843

Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

Nemai Saha, Haiwen Wang, Shengyi Zhang, Yongliang Du, Daqian Zhu, Yumin Hu, Peng Huang, Shijun Wen

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A new type of domino reaction for synthesis of heterocycles fusing the important bioactive cores, such as oxindole, indoline, and isoquinoline, is presented. Upon exposure to the very common palladium catalyst, the conceptually designed N-alkenyl iodobiaryls undergo a sequential carbopalladation/C-H activation to build polycyclic frameworks. These novel unique frameworks may provide structure sources in fragment-based drug discovery.

Original language	English (US)
Pages (from-to)	712-715
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1021/acs.orglett.7b03843
State	Published - Feb 2 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.7b03843

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abstract = "A new type of domino reaction for synthesis of heterocycles fusing the important bioactive cores, such as oxindole, indoline, and isoquinoline, is presented. Upon exposure to the very common palladium catalyst, the conceptually designed N-alkenyl iodobiaryls undergo a sequential carbopalladation/C-H activation to build polycyclic frameworks. These novel unique frameworks may provide structure sources in fragment-based drug discovery.",

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AU - Saha, Nemai

AU - Wang, Haiwen

AU - Zhang, Shengyi

AU - Du, Yongliang

AU - Zhu, Daqian

AU - Hu, Yumin

AU - Huang, Peng

AU - Wen, Shijun

PY - 2018/2/2

Y1 - 2018/2/2

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AB - A new type of domino reaction for synthesis of heterocycles fusing the important bioactive cores, such as oxindole, indoline, and isoquinoline, is presented. Upon exposure to the very common palladium catalyst, the conceptually designed N-alkenyl iodobiaryls undergo a sequential carbopalladation/C-H activation to build polycyclic frameworks. These novel unique frameworks may provide structure sources in fragment-based drug discovery.

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Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

Abstract

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