TY - JOUR
T1 - Donor-recipient mismatches in MHC class I chain-related gene a in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease
AU - Parmar, Simrit
AU - De Lima, Marcos
AU - Zou, Yizhou
AU - Patah, Poliana A.
AU - Liu, Ping
AU - Cano, Pedro
AU - Rondon, Gabriela
AU - Pesoa, Susana
AU - De Padua Silva, Leandro
AU - Qazilbash, Muzaffar H.
AU - Hosing, Chitra
AU - Popat, Uday
AU - Kebriaei, Partow
AU - Shpall, Elizabeth J.
AU - Giralt, Sergio
AU - Champlin, Richard E.
AU - Stastny, Peter
AU - Fernandez-Vina, Marcelo
PY - 2009
Y1 - 2009
N2 - The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We conclude that MICA may represent novel a transplantation antigen recognized by human allogeneic T cells. This study was registered at ClinicalTrials.gov (Identifier NCT00506922).
AB - The polymorphic products of major histocompatibility complex class I-related chain A (MICA) genes are important in solid organ transplantation rejection. MICA expression is limited to gut epithelium and may play a role in triggering acute graft-versus-host disease (aGVHD). A total of 236 recipients of unrelated donor transplantation were studied. Donor-recipient human leukocyte antigen (HLA) match was 10/10 human leukocyte antigen (HLA-A, -B, -C, -DRB1, -DQB1) in 73% and MICA mismatch in 8.4%. Because of physical vicinity of the loci, MICA mismatch was significantly associated with mismatch at HLA-B and HLA-C. A higher rate of grade II-IV aGVHD was seen in MICA-mismatched patients (80% vs 40%, P = .003) irrespective of degree of HLA matching (HLA 10/10 match: 75% vs 39%, P = .02) and HLA any mismatch (83% vs 46%, P = .003). The rate of grade II-IV gastrointestinal aGVHD was also higher in MICA-mismatched patients (35% vs 17%, P = .05). We conclude that MICA may represent novel a transplantation antigen recognized by human allogeneic T cells. This study was registered at ClinicalTrials.gov (Identifier NCT00506922).
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U2 - 10.1182/blood-2009-05-223172
DO - 10.1182/blood-2009-05-223172
M3 - Article
C2 - 19654407
AN - SCOPUS:70449490046
SN - 0006-4971
VL - 114
SP - 2884
EP - 2887
JO - Blood
JF - Blood
IS - 14
ER -