Abstract
We determined for 14 patients with acute myeloblastic leukemia, prior to therapy with an anthracycline-ara-C combination, the relationship of clinical response to dose-dependent DNA synthesis inhibition produced by each agent on each patient's cultured leukemic cells. Using a microculture system ara-C and adriamycin sensitivity (D2) was determined for each patient based upon each individual's dose response curve. The 9 patients achieving complete remission and one patient who died during induction had D2 values to both agents less than 7, while 4 non-responding patients had D2 values in excess of 9. Correlation of D2 levels with in vivo chemotherapy-induced bone marrow cytoreduction was noted for adriamycin (P < 0.005) and for ara-C (P = 0.1). A relationship between in vitro ara-C and adriamycin sensitivity (P < 0.05) suggests that they act upon similar leukemic cell populations. Inhibition of thymidine synthesis over a range of concentrations deserves further study as a rapid in vitro test for drug sensitivity in acute myeloblastic leukemia.
Original language | English (US) |
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Pages (from-to) | 549-555 |
Number of pages | 7 |
Journal | European Journal of Cancer (1965) |
Volume | 17 |
Issue number | 5 |
DOIs | |
State | Published - May 1981 |
ASJC Scopus subject areas
- General Medicine