Dose-survival characteristics of mouse jejunal crypt cells

Howard D. Thames; Rodney Withers; Kathryn A. Mason; Betty O. Reid

doi:10.1016/0360-3016(81)90091-2

Dose-survival characteristics of mouse jejunal crypt cells

Howard D. Thames, Rodney Withers, Kathryn A. Mason, Betty O. Reid

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The survival of mouse jejunal crypt cells after multiple doses of ⁶⁰Co γ-rays has been measured with the microcolony technique. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers. An average number of 152 clonogens per crypt was estimated from the experiments. The survival curve has a broad shoulder, remaining near-exponential over the initial dose range 0 to 300 rad, with initial slope ₁D₀ = 357 rad. It is not possible to distinguish between the linear-quadratic (LQ) and two-component (TC) survival models on the basis of the results of these experiments.

Original language	English (US)
Pages (from-to)	1591-1597
Number of pages	7
Journal	International journal of radiation oncology, biology, physics
Volume	7
Issue number	11
DOIs	https://doi.org/10.1016/0360-3016(81)90091-2
State	Published - Nov 1981

Keywords

Clonogens
Crypt
Fractionation
Intestinal
Radiation
Survival

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(81)90091-2

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title = "Dose-survival characteristics of mouse jejunal crypt cells",

abstract = "The survival of mouse jejunal crypt cells after multiple doses of 60Co γ-rays has been measured with the microcolony technique. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers. An average number of 152 clonogens per crypt was estimated from the experiments. The survival curve has a broad shoulder, remaining near-exponential over the initial dose range 0 to 300 rad, with initial slope 1D0 = 357 rad. It is not possible to distinguish between the linear-quadratic (LQ) and two-component (TC) survival models on the basis of the results of these experiments.",

keywords = "Clonogens, Crypt, Fractionation, Intestinal, Radiation, Survival",

author = "Thames, {Howard D.} and Rodney Withers and Mason, {Kathryn A.} and Reid, {Betty O.}",

note = "Funding Information: *Lucite. Supported in part by grants CA-I 1138, CA-29026 CA-l 1430 from the National Cancer Institute. Reprint requests to: H.D. Thames Jr., Ph.D. Accepted for publication 9 July 198 I.",

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T1 - Dose-survival characteristics of mouse jejunal crypt cells

AU - Thames, Howard D.

AU - Withers, Rodney

AU - Mason, Kathryn A.

AU - Reid, Betty O.

N1 - Funding Information: *Lucite. Supported in part by grants CA-I 1138, CA-29026 CA-l 1430 from the National Cancer Institute. Reprint requests to: H.D. Thames Jr., Ph.D. Accepted for publication 9 July 198 I.

PY - 1981/11

Y1 - 1981/11

N2 - The survival of mouse jejunal crypt cells after multiple doses of 60Co γ-rays has been measured with the microcolony technique. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers. An average number of 152 clonogens per crypt was estimated from the experiments. The survival curve has a broad shoulder, remaining near-exponential over the initial dose range 0 to 300 rad, with initial slope 1D0 = 357 rad. It is not possible to distinguish between the linear-quadratic (LQ) and two-component (TC) survival models on the basis of the results of these experiments.

AB - The survival of mouse jejunal crypt cells after multiple doses of 60Co γ-rays has been measured with the microcolony technique. Fractionation protocols were designed with common dose fractions in regimens with different fraction numbers. An average number of 152 clonogens per crypt was estimated from the experiments. The survival curve has a broad shoulder, remaining near-exponential over the initial dose range 0 to 300 rad, with initial slope 1D0 = 357 rad. It is not possible to distinguish between the linear-quadratic (LQ) and two-component (TC) survival models on the basis of the results of these experiments.

KW - Clonogens

KW - Crypt

KW - Fractionation

KW - Intestinal

KW - Radiation

KW - Survival

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Dose-survival characteristics of mouse jejunal crypt cells

Abstract

Keywords

ASJC Scopus subject areas

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