Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP

Richard E. Wendt; Alan R. Ketring; R. Keith Frank; Jaime Simón

doi:10.1016/j.apradiso.2022.110246

Dosimetric implications of the potential radionuclidic impurities in ¹⁵³Sm-DOTMP

Richard E. Wendt, Alan R. Ketring, R. Keith Frank, Jaime Simón

Imaging Physics

Research output: Contribution to journal › Article › peer-review

Abstract

Thehuman internal dosimetry of the radionuclidic impurities of samarium-153 in a new bone-seeking radiopharmaceutical, ¹⁵³Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid (¹⁵³Sm-DOTMP), has been estimated from preclinical data. The effective dose from the impurities in lower-specific-activity ¹⁵³Sm is less than 17% of the effective dose from pure Sm-153. It has a background-equivalent radiation time for a dosage of 37 MBq/kg of less than one-half year.

Original language	English (US)
Article number	110246
Journal	Applied Radiation and Isotopes
Volume	185
DOIs	https://doi.org/10.1016/j.apradiso.2022.110246
State	Published - Jul 2022

Keywords

Sm-DOTMP
Internal dosimetry
Radionuclidic impurities

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2022.110246

Cite this

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title = "Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP",

abstract = "Thehuman internal dosimetry of the radionuclidic impurities of samarium-153 in a new bone-seeking radiopharmaceutical, 153Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid (153Sm-DOTMP), has been estimated from preclinical data. The effective dose from the impurities in lower-specific-activity 153Sm is less than 17% of the effective dose from pure Sm-153. It has a background-equivalent radiation time for a dosage of 37 MBq/kg of less than one-half year.",

keywords = "Sm-DOTMP, Internal dosimetry, Radionuclidic impurities",

author = "Wendt, {Richard E.} and Ketring, {Alan R.} and Frank, {R. Keith} and Jaime Sim{\'o}n",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

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doi = "10.1016/j.apradiso.2022.110246",

language = "English (US)",

volume = "185",

journal = "Applied Radiation and Isotopes",

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AU - Wendt, Richard E.

AU - Ketring, Alan R.

AU - Frank, R. Keith

AU - Simón, Jaime

PY - 2022/7

Y1 - 2022/7

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AB - Thehuman internal dosimetry of the radionuclidic impurities of samarium-153 in a new bone-seeking radiopharmaceutical, 153Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid (153Sm-DOTMP), has been estimated from preclinical data. The effective dose from the impurities in lower-specific-activity 153Sm is less than 17% of the effective dose from pure Sm-153. It has a background-equivalent radiation time for a dosage of 37 MBq/kg of less than one-half year.

KW - Sm-DOTMP

KW - Internal dosimetry

KW - Radionuclidic impurities

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