Abstract
We present a long-circulating biodegradable corecross- linked polymeric micelle (d-CCPM) for the nuclear/optical imaging of tumors. The d-CCPM was derived from an amphiphilic block-copolymer consisting of a hydrophilic block of brush-like poly(ethylene glycol) and a hydrophobic block containing cleavable pendant triethoxysilane. The resultant imaging tracer had prolonged circulation in the blood (half-life of clearance phase = 36.5 h), substantial accumulation in tumors (% injected dose per gram of tissue = 8.5% ± 1.0% at 24 h postinjection), and minimal uptake in the liver (5.0% ± 0.1%) or spleen (5.1% ± 0.3%). Both nuclear and near-infrared fluorescence (NIRF) imaging revealed strong signals in tumor regions. At 48 h, nuclear imaging exhibited tumor-to-liver and tumor-to-blood ratios of 1.4 and 1.1, respectively. The degradation of d-CCPM was studied in vitro at pH 5.0 and 37 °C and confirmed by transmission electron microscopy. Our study indicates that the d-CCPM system is an effective probe for dual-modal cancer imaging and a potential safe platform nanocarrier for the delivery of anticancer drugs and cancer therapy.
Original language | English (US) |
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Pages (from-to) | 150-153 |
Number of pages | 4 |
Journal | ACS Macro Letters |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Jan 17 2012 |
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Inorganic Chemistry
- Materials Chemistry