TY - JOUR
T1 - Dubbing ferroptosis in cancer cells
AU - Gan, Boyi
N1 - Funding Information:
B. Gan thanks Christine Wogan of the Division of Radiation Oncology at The University of Texas MD Anderson Cancer Center (Houston, TX) for manuscript editing. B. Gan is supported by the Andrew Sabin Family Fellow Award from The University of Texas MD Anderson Cancer Center and NIH grants R01CA181196 and P30CA016672.
Publisher Copyright:
© 2019 American Association for Cancer Research.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Ferroptosis, a form of iron-dependent, nonapoptotic cell death that is induced by excessive lipid peroxidation, has been recently identified as a new tumor suppression mechanism. In this issue of Cancer Research, Liu and colleagues demonstrate that the deubiquitinase (DUB) OTUB1 is frequently overexpressed in human cancers, and functions to "dub" (trim) the ferroptosis process in cancer cells and promotes tumor development by stabilizing the cystine transporter, SLC7A11. This study not only reveals a hitherto unappreciated regulatory mechanism of ferroptosis but also identifies potential therapeutic targets for cancer treatment.
AB - Ferroptosis, a form of iron-dependent, nonapoptotic cell death that is induced by excessive lipid peroxidation, has been recently identified as a new tumor suppression mechanism. In this issue of Cancer Research, Liu and colleagues demonstrate that the deubiquitinase (DUB) OTUB1 is frequently overexpressed in human cancers, and functions to "dub" (trim) the ferroptosis process in cancer cells and promotes tumor development by stabilizing the cystine transporter, SLC7A11. This study not only reveals a hitherto unappreciated regulatory mechanism of ferroptosis but also identifies potential therapeutic targets for cancer treatment.
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U2 - 10.1158/0008-5472.CAN-19-0487
DO - 10.1158/0008-5472.CAN-19-0487
M3 - Article
C2 - 30987975
AN - SCOPUS:85064460613
SN - 0008-5472
VL - 79
SP - 1749
EP - 1750
JO - Cancer Research
JF - Cancer Research
IS - 8
ER -