TY - JOUR
T1 - Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging
AU - Macdonald-Obermann, Jennifer L.
AU - Adak, Sangeeta
AU - Landgraf, Ralf
AU - Piwnica-Worms, David
AU - Pike, Linda J.
PY - 2013/10/18
Y1 - 2013/10/18
N2 - Background: The EGF receptor, ErbB2, and ErbB3 can interact to form dimers. Results: Analyses of these interactions show that ErbB3 interacts strongly with ErbB2 but weakly with the EGF receptor. All ErbB receptor interactions are enhanced by erlotinib and lapatinib. Conclusion: ErbB3 binds and is functionally affected by tyrosine kinase inhibitors. Significance: Tyrosine kinase inhibitors restructure the network of ErbB interactions.
AB - Background: The EGF receptor, ErbB2, and ErbB3 can interact to form dimers. Results: Analyses of these interactions show that ErbB3 interacts strongly with ErbB2 but weakly with the EGF receptor. All ErbB receptor interactions are enhanced by erlotinib and lapatinib. Conclusion: ErbB3 binds and is functionally affected by tyrosine kinase inhibitors. Significance: Tyrosine kinase inhibitors restructure the network of ErbB interactions.
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U2 - 10.1074/jbc.M113.489534
DO - 10.1074/jbc.M113.489534
M3 - Article
C2 - 24014028
AN - SCOPUS:84886907697
SN - 0021-9258
VL - 288
SP - 30773
EP - 30784
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 42
ER -