TY - JOUR
T1 - Dysbiosis of gut microbiota in promoting the development of colorectal cancer
AU - Zou, Shaomin
AU - Fang, Lekun
AU - Lee, Mong Hong
N1 - Publisher Copyright:
© The Author(s) 2017.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal surface of human intestine. Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases, including colon tumorigenesis. Colorectal cancer (CRC), the third most common cancer, is the disease resulting from multi-genes and multi-factors, but the mechanistic details between gut microenvironment and CRC remain poorly characterized. Thanks to new technologies such as metagenome sequencing, progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible, which has facilitated studies about microbiota composition, taxonomic alterations and host interactions. Different bacterial species and their metabolites play critical roles in the development of CRC. Also, microbiota is important in the inflammatory response and immune processes deregulation during the development and progression of CRC. This review summarizes current studies regarding the association between gastrointestinalmicrobiota and the development of CRC, which provides insights into the therapeutic strategy of CRC.
AB - Gastrointestinal microbiome, containing at least 100 trillion bacteria, resides in the mucosal surface of human intestine. Recent studies show that perturbations in the microbiota may influence physiology and link to a number of diseases, including colon tumorigenesis. Colorectal cancer (CRC), the third most common cancer, is the disease resulting from multi-genes and multi-factors, but the mechanistic details between gut microenvironment and CRC remain poorly characterized. Thanks to new technologies such as metagenome sequencing, progress in large-scale analysis of the genetic and metabolic profile of gut microbial has been possible, which has facilitated studies about microbiota composition, taxonomic alterations and host interactions. Different bacterial species and their metabolites play critical roles in the development of CRC. Also, microbiota is important in the inflammatory response and immune processes deregulation during the development and progression of CRC. This review summarizes current studies regarding the association between gastrointestinalmicrobiota and the development of CRC, which provides insights into the therapeutic strategy of CRC.
KW - Colorectal cancer
KW - Gut microbiota
KW - Microbiome dysbiosis
KW - Tumorigenesis
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U2 - 10.1093/gastro/gox031
DO - 10.1093/gastro/gox031
M3 - Review article
C2 - 29479437
AN - SCOPUS:85047574973
SN - 2052-0034
VL - 6
SP - 1
EP - 12
JO - Gastroenterology Report
JF - Gastroenterology Report
IS - 1
ER -