TY - JOUR
T1 - Early-Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life
T2 - Findings From the REACTION Study
AU - REACTION Study Group ‡
AU - Du, Rui
AU - Zheng, Ruizhi
AU - Xu, Yu
AU - Zhu, Yuanyue
AU - Yu, Xuefeng
AU - Li, Mian
AU - Tang, Xulei
AU - Hu, Ruying
AU - Su, Qing
AU - Wang, Tiange
AU - Zhao, Zhiyun
AU - Xu, Min
AU - Chen, Yuhong
AU - Shi, Lixin
AU - Wan, Qin
AU - Chen, Gang
AU - Dai, Meng
AU - Zhang, Di
AU - Gao, Zhengnan
AU - Wang, Guixia
AU - Shen, Feixia
AU - Luo, Zuojie
AU - Qin, Yingfen
AU - Chen, Li
AU - Huo, Yanan
AU - Li, Qiang
AU - Ye, Zhen
AU - Zhang, Yinfei
AU - Liu, Chao
AU - Wang, Youmin
AU - Wu, Shengli
AU - Yang, Tao
AU - Deng, Huacong
AU - Chen, Lulu
AU - Zhao, Jiajun
AU - Mu, Yiming
AU - Li, Donghui
AU - Qin, Guijun
AU - Wang, Weiqing
AU - Ning, Guang
AU - Yan, Li
AU - Bi, Yufang
AU - Lu, Jieli
PY - 2020/4/7
Y1 - 2020/4/7
N2 - Background Previous studies reported that early-life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community-dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable-adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20-1.52), 1.59 (1.08-2.35), 1.40 (1.11-1.78), and 1.44 (1.26-1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40-1.81), 2.20 (1.52-3.20), 1.82 (1.45-2.28), and 1.80 (1.56-2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27-1.81), 2.07 (1.28-3.35), 1.92 (1.42-2.58), and 1.83 (1.50-2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early-life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area.
AB - Background Previous studies reported that early-life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community-dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable-adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20-1.52), 1.59 (1.08-2.35), 1.40 (1.11-1.78), and 1.44 (1.26-1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40-1.81), 2.20 (1.52-3.20), 1.82 (1.45-2.28), and 1.80 (1.56-2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27-1.81), 2.07 (1.28-3.35), 1.92 (1.42-2.58), and 1.83 (1.50-2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early-life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area.
KW - association
KW - cardiovascular diseases
KW - early‐life exposure
KW - famine
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U2 - 10.1161/JAHA.119.014175
DO - 10.1161/JAHA.119.014175
M3 - Article
C2 - 32233751
SN - 2047-9980
VL - 9
SP - e014175
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 7
ER -