TY - JOUR
T1 - Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant
AU - Goldberg, Jenna D.
AU - Zheng, Junting
AU - Ratan, Ravin
AU - Small, Trudy N.
AU - Lai, Kuan Chi
AU - Boulad, Farid
AU - Castro-Malaspina, Hugo
AU - Giralt, Sergio A.
AU - Jakubowski, Ann A.
AU - Kernan, Nancy A.
AU - O’Reilly, Richard J.
AU - Papadopoulos, Esperanza B.
AU - Young, James W.
AU - van den Brink, Marcel R.M.
AU - Heller, Glenn
AU - Perales, Miguel Angel
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/8/3
Y1 - 2017/8/3
N2 - Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT.
AB - Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT.
KW - Immune reconstitution
KW - T-cell depletion
KW - allogeneic hematopoietic stem cell transplant
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U2 - 10.1080/10428194.2016.1265113
DO - 10.1080/10428194.2016.1265113
M3 - Article
C2 - 28073320
AN - SCOPUS:85009284477
SN - 1042-8194
VL - 58
SP - 1859
EP - 1871
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -