Abstract
Backround: Current evidence suggests that oncologic surgery, therapeutics used in treatment of solid tumors, may paradoxically increase the risk of metastasis due to stress, immunosuppression, and perioperative inflammation. Lidocaine is an amide-type local anesthetic commonly used in oncologic surgery. Lidocaine has analgesic, anti-inflammatory and immunomodulatory properties, allowing it to reduce the neuroendocrine response to stress. Preclinical studies also indicate that lidocaine in vitro and in vivo induces cytotoxic effects by interfering with the pathogenic processes of tumor progression and metastasis. Objectives: In this context, the working hypothesis of several clinical investigations has been that intravenous administration of lidocaine perioperatively would reduce tumor progression. This narrative review aims to summarize the current evidence on the antiproliferative mechanisms of lidocaine and its possible influence on cancer recurrence.
Translated title of the contribution | Antiproliferative effects of intravenous lidocaine and recurrence of cancer and cancer recurrence |
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Original language | Spanish |
Pages (from-to) | 768-775 |
Number of pages | 8 |
Journal | Revista Chilena de Anestesia |
Volume | 52 |
Issue number | 8 |
DOIs | |
State | Published - Nov 2023 |
Externally published | Yes |
Keywords
- antiproliferation
- cancer
- Lidocaine
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine