TY - JOUR
T1 - Effect of acetone administered in vivo upon hepatic microsomal drug metabolizing activity in the rat
AU - Clark, Helen
AU - Powis, Garth
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1974/3/1
Y1 - 1974/3/1
N2 - The effects of acetone administered to female rats in vivo, upon the metabolism of drugs by the hepatic microsomal subcellular fraction have been studied. There is a rapid increase, maximal at 0·5 hr in aniline p-hydroxylation of 69 per cent, and an inhibition of aminopyrine N-demethylation of 61 per cent. Thereafter levels return to control values. There is a slower increase in aniline p-hydroxylation of 168 per cent, maximal at 48 hr. whilst aminopyrine N-demethylation is unaltered. Cycloheximide has no effect upon the changes in activity after 0·5 hr but blocks the increase in aniline p-hydroxylation 48 hr after the administration of acetone. It is suggested that acetone may contribute to the changes in drug metabolizing activity found in diabetic animals.
AB - The effects of acetone administered to female rats in vivo, upon the metabolism of drugs by the hepatic microsomal subcellular fraction have been studied. There is a rapid increase, maximal at 0·5 hr in aniline p-hydroxylation of 69 per cent, and an inhibition of aminopyrine N-demethylation of 61 per cent. Thereafter levels return to control values. There is a slower increase in aniline p-hydroxylation of 168 per cent, maximal at 48 hr. whilst aminopyrine N-demethylation is unaltered. Cycloheximide has no effect upon the changes in activity after 0·5 hr but blocks the increase in aniline p-hydroxylation 48 hr after the administration of acetone. It is suggested that acetone may contribute to the changes in drug metabolizing activity found in diabetic animals.
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U2 - 10.1016/0006-2952(74)90031-8
DO - 10.1016/0006-2952(74)90031-8
M3 - Article
C2 - 4376403
AN - SCOPUS:0015979418
SN - 0006-2952
VL - 23
SP - 1015
EP - 1019
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 5
ER -