TY - JOUR
T1 - Effect of chronic ethanol consumption on liver metabolites in Sinclair (S-1) miniature swine
AU - Kusewitt, D. F.
AU - Burke, J. P.
AU - Tumbleson, M. E.
N1 - Funding Information:
Ethanol has been shown to interfere with the metabolism of lipids, both in man and animals. It results in such diverse actions as increased lipid mobilization (Middieton et al., 1971), decreased hepatic oxidation of lipids (Reboucas & Isselbacher, 1961), and inhibition of hepatic lipogenesis (Scholz et al., 1973). Under certain experimental conditions, ethanol has been shown to increase intestinal cholesterolgenesis (Middleton et al., 1971) and triacylglycerol synthesis (Carter et al., 1971). In addition, it has been shown that ethanol shifts the liver redox state to a more reduced level and the ratio of substrate pairs (lactate/ pyruvate and/~-hydroxybutyrate/acetoacetate) in the blood increases during ethanol oxidation (Forsander, * Supported in part by USPHS grant RR-00390 and a grant from the United States Brewers Association, Ihc. 1"Present address: Pennsylvania College of Pediatric Medicine, Philadelphia, PA 19107, U.S.A.
PY - 1977
Y1 - 1977
N2 - 1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.
AB - 1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.
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U2 - 10.1016/0306-3623(77)90010-6
DO - 10.1016/0306-3623(77)90010-6
M3 - Article
C2 - 203510
AN - SCOPUS:0017571132
SN - 0306-3623
VL - 8
SP - 335
EP - 339
JO - General Pharmacology
JF - General Pharmacology
IS - 5-6
ER -