Effect of dammaran triterpene glycosides and their aglycones on K⁺ and H⁺ flows in erythrocytes induced by ionophore A23187 and bivalent ions

The influence of the dammaran triterpene glycosides Rb1, Rb2, Rg1 and Rf and their aglycones 20(S) protopanaxatriole and 20(S) protopanaxadiole on fluctuation of the K⁺ and H⁺ flows in erythrocytes induced be ionophore A23187 and Ca²⁺ was studied. It was shown that glycoside Rb1 (10 to 50 μg/ml) and 20(S) protopanaxatriole (30 μg/ml) had a property of inducing fluctuation of the K⁺ and H⁺ flows in erythrocytes. In case of Rb1 the system entirely reversed to the initial state whereas in case of the protopanaxatriole use after the fluctuation the system did not reverse to the initial state. Glycosides Rb2 (10 to 30 μg/ml), Rg1 (5 to 20 μg/ml) and Rf (10 to 100 μg/ml) and 20(S) protopanaxadiole (30 μg/ml) in the concentrations used did not initiate the fluctuations. The above substances increased the extracellular concentration of K⁺ and pH without the system reversion to the initial state.