TY - JOUR
T1 - Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer
AU - Touillaud, Marina S.
AU - Pillow, Patricia C.
AU - Jakovljevic, Jelena
AU - Bondy, Melissa L.
AU - Eva Singletary, S.
AU - Li, Donghui
AU - Chang, Shine
N1 - Funding Information:
We thank Julie Alderfer, R.N., of the Department of Surgical Oncology, and Elaine S. Petrulis, M.P.H, and Farzana L. Walcott, M.S., research coordinators in the Department of Epidemiology of The University of Texas M. D. Anderson Cancer Center, for their work in collecting data used in these analyses. This work was supported in part by a grant from the National Cancer Institute (CA70264, to Drs. Donghui Li and Melissa L. Bondy); by funds from the M. D. Anderson Breast Cancer Program and a grant from the US Department of Defense Congressionally Directed Medical Research Program in Breast Cancer (S/C DAMD 179616292, to Dr. S. Eva Singletary); and by a Clinical Research Training Grant for Junior Faculty from the American Cancer Society (to Dr. Shine Chang). Address correspondence to S. Chang, Office of Preventive Oncology, National Cancer Institute, Suite 321, MSC 7361, 6130 Executive Blvd, Bethesda MD 20892–7361. Phone: (301) 496–8640. FAX: (301) 480–2669. E-mail: ChangSH@mail.nih.gov.
PY - 2005
Y1 - 2005
N2 - Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR = 3.50; 95% confidence interval, CI = 1.43-8.58) and daidzein (OR = 3.70; 95% CI = 1.31-7.30). Low intake of the flavonoid kaempferol (OR = 0.36; 95% CI = 0.16-0.83), the trace element boron (OR = 0.33; 95% CI = 0.13-0.83), and the phytosterol β-sitosterol (OR = 0.42; 95% CI = 0.18-0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment.
AB - Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR = 3.50; 95% confidence interval, CI = 1.43-8.58) and daidzein (OR = 3.70; 95% CI = 1.31-7.30). Low intake of the flavonoid kaempferol (OR = 0.36; 95% CI = 0.16-0.83), the trace element boron (OR = 0.33; 95% CI = 0.13-0.83), and the phytosterol β-sitosterol (OR = 0.42; 95% CI = 0.18-0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment.
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U2 - 10.1207/s15327914nc5102_6
DO - 10.1207/s15327914nc5102_6
M3 - Article
C2 - 15860438
AN - SCOPUS:19544384386
SN - 0163-5581
VL - 51
SP - 162
EP - 169
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 2
ER -