Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified paclitaxel

Jacob M. Berlin; Ashley D. Leonard; Tam T. Pham; Daisuke Sano; Daniela C. Marcano; Shayou Yan; Stefania Fiorentino; Zvonimir L. Milas; Dmitry V. Kosynkin; B. Katherine Price; Rebecca M. Lucente-Schultz; Xiaoxia Wen; M. Gabriela Raso; Suzanne L. Craig; Hai T. Tran; Jeffrey N. Myers; James M. Tour

doi:10.1021/nn100975c

Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified paclitaxel

Jacob M. Berlin, Ashley D. Leonard, Tam T. Pham, Daisuke Sano, Daniela C. Marcano, Shayou Yan, Stefania Fiorentino, Zvonimir L. Milas, Dmitry V. Kosynkin, B. Katherine Price, Rebecca M. Lucente-Schultz, Xiaoxia Wen, M. Gabriela Raso, Suzanne L. Craig, Hai T. Tran, Jeffrey N. Myers, James M. Tour

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) Is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mixed with paclitaxel. This formulation of PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) is stable for at least 20 weeks. The PTX/ PEG-HCCs formulation was as effective as PTX in a clinical formulation in reducing tumor volumes in an orthotopic murine model of oral squamous cell carcinoma. Preliminary toxicity and biodistribution studies suggest that the PEG-HCCs are not acutely toxic and, like many other nanomaterials, are primarily accumulated in the liver and spleen. This work demonstrates that carbon nanomaterials are effective drug delivery vehicles in vivo when noncovalently loaded with an unmodified drug.

Original language	English (US)
Pages (from-to)	4621-4636
Number of pages	16
Journal	ACS Nano
Volume	4
Issue number	8
DOIs	https://doi.org/10.1021/nn100975c
State	Published - Aug 24 2010

Keywords

Biodistribution
Cancer
Carbon nanotechnology
Drug delivery
Toxicity

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/nn100975c

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Berlin, J. M., Leonard, A. D., Pham, T. T., Sano, D., Marcano, D. C., Yan, S., Fiorentino, S., Milas, Z. L., Kosynkin, D. V., Price, B. K., Lucente-Schultz, R. M., Wen, X., Raso, M. G., Craig, S. L., Tran, H. T., Myers, J. N., & Tour, J. M. (2010). Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified paclitaxel. ACS Nano, 4(8), 4621-4636. https://doi.org/10.1021/nn100975c

Berlin, JM, Leonard, AD, Pham, TT, Sano, D, Marcano, DC, Yan, S, Fiorentino, S, Milas, ZL, Kosynkin, DV, Price, BK, Lucente-Schultz, RM, Wen, X , Raso, MG, Craig, SL, Tran, HT , Myers, JN & Tour, JM 2010, 'Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified paclitaxel', ACS Nano, vol. 4, no. 8, pp. 4621-4636. https://doi.org/10.1021/nn100975c

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abstract = "Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) Is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mixed with paclitaxel. This formulation of PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) is stable for at least 20 weeks. The PTX/ PEG-HCCs formulation was as effective as PTX in a clinical formulation in reducing tumor volumes in an orthotopic murine model of oral squamous cell carcinoma. Preliminary toxicity and biodistribution studies suggest that the PEG-HCCs are not acutely toxic and, like many other nanomaterials, are primarily accumulated in the liver and spleen. This work demonstrates that carbon nanomaterials are effective drug delivery vehicles in vivo when noncovalently loaded with an unmodified drug.",

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AU - Lucente-Schultz, Rebecca M.

AU - Wen, Xiaoxia

AU - Raso, M. Gabriela

AU - Craig, Suzanne L.

AU - Tran, Hai T.

AU - Myers, Jeffrey N.

AU - Tour, James M.

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N2 - Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) Is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mixed with paclitaxel. This formulation of PTX sequestered in PEG-HCCs (PTX/PEG-HCCs) is stable for at least 20 weeks. The PTX/ PEG-HCCs formulation was as effective as PTX in a clinical formulation in reducing tumor volumes in an orthotopic murine model of oral squamous cell carcinoma. Preliminary toxicity and biodistribution studies suggest that the PEG-HCCs are not acutely toxic and, like many other nanomaterials, are primarily accumulated in the liver and spleen. This work demonstrates that carbon nanomaterials are effective drug delivery vehicles in vivo when noncovalently loaded with an unmodified drug.

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Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified paclitaxel

Abstract

Keywords

ASJC Scopus subject areas

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