TY - JOUR
T1 - Effectiveness of an oxidized cellulose patch hemostatic agent in thyroid surgery
T2 - A prospective, randomized, controlled study
AU - Amit, Moran
AU - Binenbaum, Yoav
AU - Cohen, Jacob T.
AU - Gil, Ziv
N1 - Funding Information:
We would like to thank Dr Jennifer Lonier for critically reading the manuscript and for her comments and many fruitful discussions. Dr Geoff Woods for taking the low-frequency IR spectra, Dr H. Kanda (NIRIM) for supplying the I3C diamonds and Mr L. Rossou (Rijksumversitair Centrum le Antwerpen) for ion beam thinning the specimens. Financial assistance for one of us (J.B.) was provided by the National Science Foundation under grant DMR 93-0625.
PY - 2013/8
Y1 - 2013/8
N2 - Background: This single-blinded, prospective, randomized controlled trial compared the efficacy and safety of an oxidized cellulose patch (Surgicel [Johnson and Johnson]) with conventional procedures for achieving hemostasis in thyroid surgery. Study Design: The study included 190 patients scheduled for thyroidectomy. Patients were randomized into 1 conventionally treated (ligatures and bipolar electrocautery) group (n = 92) and a second group, which additionally received Surgicel (n = 98). Results: The groups were demographically and clinically matched and had similar wound drainage volumes and mean duration of surgery. Postoperative bleeding rate was greater in the Surgicel group, yet the difference didn't reach statistical significance (p = 0.054). There were no significant group differences in postoperative wound infection, seroma, hypocalcemia, or recurrent laryngeal nerve palsy. Time to drain removal and length of hospital stay were significantly shorter in the conventional group (p < 0.001). Conclusions: Routine use of an oxidized cellulose hemostatic agent has no advantage over conventional hemostasis and is potentially harmful in thyroid surgery.
AB - Background: This single-blinded, prospective, randomized controlled trial compared the efficacy and safety of an oxidized cellulose patch (Surgicel [Johnson and Johnson]) with conventional procedures for achieving hemostasis in thyroid surgery. Study Design: The study included 190 patients scheduled for thyroidectomy. Patients were randomized into 1 conventionally treated (ligatures and bipolar electrocautery) group (n = 92) and a second group, which additionally received Surgicel (n = 98). Results: The groups were demographically and clinically matched and had similar wound drainage volumes and mean duration of surgery. Postoperative bleeding rate was greater in the Surgicel group, yet the difference didn't reach statistical significance (p = 0.054). There were no significant group differences in postoperative wound infection, seroma, hypocalcemia, or recurrent laryngeal nerve palsy. Time to drain removal and length of hospital stay were significantly shorter in the conventional group (p < 0.001). Conclusions: Routine use of an oxidized cellulose hemostatic agent has no advantage over conventional hemostasis and is potentially harmful in thyroid surgery.
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U2 - 10.1016/j.jamcollsurg.2013.03.022
DO - 10.1016/j.jamcollsurg.2013.03.022
M3 - Article
C2 - 23870217
AN - SCOPUS:84880558271
SN - 1072-7515
VL - 217
SP - 221
EP - 225
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
IS - 2
ER -