TY - JOUR
T1 - Effectiveness, safety, and acceptability of cryotherapy by midwives for cervical intraepithelial neoplasia in Maharashtra, India
AU - Nene, Bhagwan M.
AU - Hiremath, Pragna S.
AU - Kane, Subhadha
AU - Fayette, Jean Marie
AU - Shastri, Surendra S.
AU - Sankaranarayanan, Rengaswamy
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2008/12
Y1 - 2008/12
N2 - Objective: To evaluate the effectiveness, safety, and acceptability of cryotherapy for cervical intraepithelial neoplasia (CIN) when provided by trained midwives in rural India. Method: Women with colposcopic findings of CIN lesions suitable for ablative treatment received cryotherapy from trained midwives before the biopsy results were known. Cure rates, adverse effects, and complications were assessed and factors influencing cure rates were evaluated by χ2 tests. Cure was defined as no clinical or histologic evidence of CIN lesions 6 or more months after treatment. Results: Of 1068 women treated with cryotherapy, 728 had histologically proven CIN in their pretreatment biopsy specimens; of the 574 reporting for follow-up, 538 (93.7%) were cured (95% confidence interval [CI], 92.1%-96.3%). Cure rates were 96.4% (95% CI, 94.6%-98.1%) for CIN 1 and 82.1% (95% CI, 74.7%-89.4%) for CIN 2 and CIN 3 lesions combined. Minor adverse effects were documented in 5.2% of the women. Conclusion: Cryotherapy provided by midwives was found to be safe, effective, and acceptable by the women.
AB - Objective: To evaluate the effectiveness, safety, and acceptability of cryotherapy for cervical intraepithelial neoplasia (CIN) when provided by trained midwives in rural India. Method: Women with colposcopic findings of CIN lesions suitable for ablative treatment received cryotherapy from trained midwives before the biopsy results were known. Cure rates, adverse effects, and complications were assessed and factors influencing cure rates were evaluated by χ2 tests. Cure was defined as no clinical or histologic evidence of CIN lesions 6 or more months after treatment. Results: Of 1068 women treated with cryotherapy, 728 had histologically proven CIN in their pretreatment biopsy specimens; of the 574 reporting for follow-up, 538 (93.7%) were cured (95% confidence interval [CI], 92.1%-96.3%). Cure rates were 96.4% (95% CI, 94.6%-98.1%) for CIN 1 and 82.1% (95% CI, 74.7%-89.4%) for CIN 2 and CIN 3 lesions combined. Minor adverse effects were documented in 5.2% of the women. Conclusion: Cryotherapy provided by midwives was found to be safe, effective, and acceptable by the women.
KW - Cervical cancer
KW - Cervical intraepithelial neoplasia
KW - Cryotherapy
KW - Safety
KW - Screening
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U2 - 10.1016/j.ijgo.2008.07.016
DO - 10.1016/j.ijgo.2008.07.016
M3 - Article
C2 - 18817909
AN - SCOPUS:55949124157
SN - 0020-7292
VL - 103
SP - 232
EP - 236
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
IS - 3
ER -