TY - JOUR
T1 - Effects of calcium mediated secretagogues on the growth of pancreatic acinar cells in vitro
AU - Logsdon, C. D.
PY - 1987
Y1 - 1987
N2 - Caerulein, CCK8, and gastrin, hormones which interact with the cholecystokinin receptor increased the growth of mouse pancreatic acinar cells in vitro. In contrast, bombesin, substance P, and carbachol, factors which interact with separate receptors, and stimulate pancreatic secretion similarly to CCK by mobilising intracellular Ca2+, did not have any effect on the growth of pancreatic acinar cells in vitro. These results suggest both a unique role for cholecystokinin in the physiological regulation of the pancreas and that the mechanisms that mediate the trophic effects of cholecystokinin are different from those that mediate secretion.
AB - Caerulein, CCK8, and gastrin, hormones which interact with the cholecystokinin receptor increased the growth of mouse pancreatic acinar cells in vitro. In contrast, bombesin, substance P, and carbachol, factors which interact with separate receptors, and stimulate pancreatic secretion similarly to CCK by mobilising intracellular Ca2+, did not have any effect on the growth of pancreatic acinar cells in vitro. These results suggest both a unique role for cholecystokinin in the physiological regulation of the pancreas and that the mechanisms that mediate the trophic effects of cholecystokinin are different from those that mediate secretion.
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U2 - 10.1136/gut.28.Suppl.117
DO - 10.1136/gut.28.Suppl.117
M3 - Article
C2 - 2446961
AN - SCOPUS:0023476316
SN - 0017-5749
VL - 28
SP - 117
EP - 120
JO - Gut
JF - Gut
IS - SUPPL.1
ER -