Abstract
Cryogen spray cooling (CSC) is an effective method to reduce or eliminate epidermal damage during laser treatment of various dermatoses. This study sought to determine the effects of specific cryogen properties on heat removal. Heat removal was quantified using an algorithm that solved an inverse heat conduction problem from internal temperature measurements made within a skin phantom. A nondimensional parameter, the Weber number, characterized the combined effects of droplet velocity, diameter, and surface tension. CSC experiments with laser irradiation were conducted on ex vivo human skin samples to assess the effect of Weber number on epidermal protection. An empirical relationship between heat removal and the difference in droplet temperature and the substrate, droplet velocity, and diameter was obtained. Histological sections of irradiated ex vivo human skin demonstrated that sprays with higher Weber numbers increased epidermal protection. Results indicate that the cryogen film acts as an impediment to heat transfer between the impinging droplets and the substrate. This study offers the importance of Weber number in heat removal and epidermal protection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1131-1140 |
| Number of pages | 10 |
| Journal | Annals of Biomedical Engineering |
| Volume | 32 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2004 |
Keywords
- Dermatology
- Laser therapy
- Skin
- Surface tension
- Surfactants
- Weber number
ASJC Scopus subject areas
- Biomedical Engineering