Abstract
This study was initiated to determine the time course of estrogen action in individual uterine cell types of the immature rat uterus. Animals were treated with a single injection of estradiol-17β for various times and colchicine was administered 4 h prior to sacrifice. In the luminal epithelium a peak of arrested mitoses was observed 24 h after hormone administration and represent ~12% of the cell population. In contrast both the stroma and myometrium displayed a peak of arrested mitoses 36-48 h after hormone administration and the maximum value represented ~1% of the total cell populations. These results indicate that the patterns of estrogen-induced cell division are quantitatively and qualitatively distinct in the different cell types of the immature rat uterus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 269-272 |
| Number of pages | 4 |
| Journal | Biology of reproduction |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1979 |
ASJC Scopus subject areas
- Reproductive Medicine
- Cell Biology