TY - CHAP
T1 - Effects of inorganic arsenic on bone marrow hematopoietic cells
T2 - An emphasis on apoptosis and Sca-1/c-Kit positive population
AU - Pereira, Jacintha Archana
AU - Das, Prosun
AU - Chaklader, Malay
AU - Chatterjee, Sumanta
AU - Basak, Pratima
AU - Chaudhur, Samaresh
AU - Law, Sujata
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2012/12
Y1 - 2012/12
N2 - Apoptosis, proliferation and differentiation are balanced molecular processes which may alter their pattern during environmental insults. Arsenic is an environmental pollutant, ranks 20th in abundance in the earth crust, 14th in sea water and 12th in the human body. Millions of people worldwide are chronically exposed to arsenic often due to naturally occurring arsenic in ground water. Hematopoietic stem cells within the bone marrow are the source of all haematopoietic cell lineages and are essential for tissue development throughout the life. In this experimental study, we have evaluated the impact of arsenic, on blood and blood forming cells by the changes in their cellular morphology, immune functional capacity, alteration of bone marrow CD34 positive stem/progenitors and changes in the phenotype of Sca-1, c-Kit dual positive primitive stem cell population. The study revealed that arsenic has a significant effect on bone marrow and hematopoietic stem cells, their immune capacity and upregulation of death process, all indicative of impairment in differentiation suggesting presence of deregulation in their precursors by arsenic toxicity.
AB - Apoptosis, proliferation and differentiation are balanced molecular processes which may alter their pattern during environmental insults. Arsenic is an environmental pollutant, ranks 20th in abundance in the earth crust, 14th in sea water and 12th in the human body. Millions of people worldwide are chronically exposed to arsenic often due to naturally occurring arsenic in ground water. Hematopoietic stem cells within the bone marrow are the source of all haematopoietic cell lineages and are essential for tissue development throughout the life. In this experimental study, we have evaluated the impact of arsenic, on blood and blood forming cells by the changes in their cellular morphology, immune functional capacity, alteration of bone marrow CD34 positive stem/progenitors and changes in the phenotype of Sca-1, c-Kit dual positive primitive stem cell population. The study revealed that arsenic has a significant effect on bone marrow and hematopoietic stem cells, their immune capacity and upregulation of death process, all indicative of impairment in differentiation suggesting presence of deregulation in their precursors by arsenic toxicity.
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M3 - Chapter
AN - SCOPUS:84895351526
SN - 9781622571697
SP - 87
EP - 101
BT - Stem Cells in Disease
PB - Nova Science Publishers, Inc.
ER -