Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

Rose Marie Bluthé; Robert Dantzer; Keith W. Kelley

doi:10.1016/0006-8993(92)90779-9

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

Rose Marie Bluthé, Robert Dantzer, Keith W. Kelley

Research output: Contribution to journal › Article › peer-review

255 Scopus citations

Abstract

To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 μg/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 μg/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.

Original language	English (US)
Pages (from-to)	318-320
Number of pages	3
Journal	Brain Research
Volume	573
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)90779-9
State	Published - Feb 28 1992
Externally published	Yes

Keywords

Interleukin-1
Interleukin-1 receptor antagonist
Lipopolysaccharide
Rat
Social behavior

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(92)90779-9

Cite this

@article{405f5b9edcf44e8f95581b7c50f7ede2,

title = "Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat",

abstract = "To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 μg/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 μg/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.",

keywords = "Interleukin-1, Interleukin-1 receptor antagonist, Lipopolysaccharide, Rat, Social behavior",

author = "Bluth{\'e}, {Rose Marie} and Robert Dantzer and Kelley, {Keith W.}",

note = "Funding Information: Many thanks are due to Dr. J. Vannice (Synergen, Boulder, CO) for the supply of IL-lra and his useful comments on the manuscript. This work was supported by INRA-INSERM and grants from ONR (N00014-89-J-1956, K.W.K.) and DRET (N°90-166, R.D.).",

year = "1992",

month = feb,

day = "28",

doi = "10.1016/0006-8993(92)90779-9",

language = "English (US)",

volume = "573",

pages = "318--320",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

AU - Bluthé, Rose Marie

AU - Dantzer, Robert

AU - Kelley, Keith W.

N1 - Funding Information: Many thanks are due to Dr. J. Vannice (Synergen, Boulder, CO) for the supply of IL-lra and his useful comments on the manuscript. This work was supported by INRA-INSERM and grants from ONR (N00014-89-J-1956, K.W.K.) and DRET (N°90-166, R.D.).

PY - 1992/2/28

Y1 - 1992/2/28

N2 - To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 μg/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 μg/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.

AB - To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 μg/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 μg/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.

KW - Interleukin-1

KW - Interleukin-1 receptor antagonist

KW - Lipopolysaccharide

KW - Rat

KW - Social behavior

UR - http://www.scopus.com/inward/record.url?scp=0026599095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026599095&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(92)90779-9

DO - 10.1016/0006-8993(92)90779-9

M3 - Article

C2 - 1387028

AN - SCOPUS:0026599095

SN - 0006-8993

VL - 573

SP - 318

EP - 320

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this