Abstract
The aim of this study was to determine the effects of low doses of tamoxifen (5 and 10mg/day) for 50 days compared with the standard dose (20 mg/day) on breast biomarkers measured in normal breast tissue from premenopausal patients. A randomised double-blind study was performed using tissue from 56 premenopausal women with a diagnosis of fibroadenoma of the breast. Excisional biopsy was performed on the 50th day of therapy. Normal breast tissue samples were collected during surgery. The patients were divided in groups: A (placebo, n=11); group B (5 mg, n=16), group C (10 mg, n=14) and group D (20 mg, n=15). In this cross-sectional study, differences in the expression of Oestrogen Receptor alpha (ERα), Progesterone Receptor (PR), Ki-67, apoptotic bodies and mitotic index between the different groups after treatment can be seen on the normal breast tissue. We believe that a lower dose of tamoxifen could reduce the side-effects associated with treatment without affecting its chemopreventive activity in the breast.
Original language | English (US) |
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Pages (from-to) | 891-898 |
Number of pages | 8 |
Journal | European Journal of Cancer |
Volume | 39 |
Issue number | 7 |
DOIs | |
State | Published - May 2003 |
Externally published | Yes |
Keywords
- Breast biomarkers
- Normal breast tissue
- Premenopausal
- Tamoxifen
ASJC Scopus subject areas
- Oncology
- Cancer Research