TY - JOUR
T1 - Effects of methamphetamine on the noradrenergic activity biomarker salivary alpha-amylase
AU - Haile, Colin N.
AU - De La Garza, Richard
AU - Mahoney, James J.
AU - Newton, Thomas F.
N1 - Funding Information:
Funding for this study was provided by NIH (TF Newton : R25DA28976 , R01DA023468 , P50DA18197 ). The NIH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Background: Methamphetamine (METH) potently activates the sympathetic nervous system (SNS) by increasing central and peripheral norepinephrine (NE). Salivary α-amylase (sAA) is a biomarker of SNS activation that correlates with plasma NE levels. The purpose of this study was to determine the impact of METH on sAA activity and whether changes in sAA activity were correlated with subjective effects ratings. Methods: Non-treatment seeking METH-dependent volunteers (N= 8) participated in this within-subjects laboratory-based study. Volunteers received randomly administered intravenous METH (0. mg, 30. mg) and sAA activity, cardiovascular measures and subjective ratings were assessed at baseline (-15. min) and five post-METH time points (10, 20, 30, 45, and 60. min). Results: METH (30. mg) increased sAA activity over time. sAA activity significantly correlated with diastolic blood pressure following 0. mg METH and systolic blood pressure following 30. mg METH. Subjective ratings (ANY EFFECT, HIGH, GOOD, STIMULATED, LIKE, WLLING TO PAY) highly correlated with sAA over five post-METH time points (N= 40; r's. = 0.543-0.684, p's. <. 0.001). Age, body mass index and METH amount received on a mg/kg basis were significantly associated with sAA activity. Multiple linear regression analysis indicated sAA activity remained a significant predictor of subjective ratings following METH after controlling for these factors. Conclusions: The NE peripheral biomarker sAA activity is associated with METH's subjective effects.
AB - Background: Methamphetamine (METH) potently activates the sympathetic nervous system (SNS) by increasing central and peripheral norepinephrine (NE). Salivary α-amylase (sAA) is a biomarker of SNS activation that correlates with plasma NE levels. The purpose of this study was to determine the impact of METH on sAA activity and whether changes in sAA activity were correlated with subjective effects ratings. Methods: Non-treatment seeking METH-dependent volunteers (N= 8) participated in this within-subjects laboratory-based study. Volunteers received randomly administered intravenous METH (0. mg, 30. mg) and sAA activity, cardiovascular measures and subjective ratings were assessed at baseline (-15. min) and five post-METH time points (10, 20, 30, 45, and 60. min). Results: METH (30. mg) increased sAA activity over time. sAA activity significantly correlated with diastolic blood pressure following 0. mg METH and systolic blood pressure following 30. mg METH. Subjective ratings (ANY EFFECT, HIGH, GOOD, STIMULATED, LIKE, WLLING TO PAY) highly correlated with sAA over five post-METH time points (N= 40; r's. = 0.543-0.684, p's. <. 0.001). Age, body mass index and METH amount received on a mg/kg basis were significantly associated with sAA activity. Multiple linear regression analysis indicated sAA activity remained a significant predictor of subjective ratings following METH after controlling for these factors. Conclusions: The NE peripheral biomarker sAA activity is associated with METH's subjective effects.
KW - Methamphetamine
KW - Norepinephrine
KW - Psychostimulants
KW - Salivary alpha-amylase
KW - Sympathetic nervous system
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U2 - 10.1016/j.drugalcdep.2013.07.029
DO - 10.1016/j.drugalcdep.2013.07.029
M3 - Article
C2 - 23968815
AN - SCOPUS:84887020315
SN - 0376-8716
VL - 133
SP - 759
EP - 762
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 2
ER -