@inproceedings{783a188d113841e3a88adcaffac43d66,
title = "Effects of non-stationary blur on texture biomarkers of bone using ultra-high resolution CT",
abstract = "Purpose: To advance the development of radiomic models of bone quality using the recently introduced Ultra-High Resolution CT (UHR CT), we investigate inter-scan reproducibility of trabecular bone texture features to spatially-variant azimuthal and radial blurs associated with focal spot elongation and gantry rotation. Methods: The UHR CT system features 250x250 μm detector pixels and an x-ray source with a 0.4x0.5 mm focal spot. Visualization of details down to ∼150 μm has been reported for this device. A cadaveric femur was imaged on UHR CT at three radial locations within the field-of-view: 0 cm (isocenter), 9 cm from the isocenter, and 18 cm from the isocenter; we expect the non-stationary blurs to worsen with increasing radial displacement. Gray level cooccurrence (GLCM) and gray level run length (GLRLM) texture features were extracted from 237 trabecular regions of interest (ROIs, 5 cm diameter) placed at corresponding locations in the femoral head in scans obtained at the different shifts. We evaluated concordance correlation coefficient (CCC) between texture features at 0 cm (reference) and at 9 cm and 18 cm. We also investigated whether the spatially-variant blurs affect K-means clustering of trabecular bone ROIs based on their texture features. Results: The average CCCs (against the 0 cm reference) for GLCM and GLRM features were ∼0.7 at 9 cm. At 18 cm, the average CCCs were reduced to ∼0.17 for GLCM and ∼0.26 for GLRM. The non-stationary blurs are incorporated in radiomic features of cancellous bone, leading to inconsistencies in clustering of trabecular ROIs between different radial locations: an intersection-over-union overlap of corresponding (most similar) clusters between 0 cm and 9 cm shift was >70%, but dropped to <60% for the majority of corresponding clusters between 0 cm and 18 cm shift. Conclusion: Non-stationary CT system blurs reduce inter-scan reproducibility of texture features of trabecular bone in UHR CT, especially for locations <15 cm from the isocenter. Radiomic models of bone quality derived from UHR CT measurements at isocenter might need to be revised before application in peripheral body sites such as the hips.",
keywords = "bone imaging, bone microstructure, high resolution CT, quantitative CT, radiomics, texture analysis",
author = "G. Shi and {Quevedo Gonzalez}, {F. J.} and Breighneer, {R. E.} and Carrino, {J. A.} and Siewerdsen, {J. H.} and W. Zbijewski",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 19-02-2023 Through 22-02-2023",
year = "2023",
doi = "10.1117/12.2654304",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Gimi, {Barjor S.} and Andrzej Krol",
booktitle = "Medical Imaging 2023",
}