Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma

Wei Lu; Marites P. Melancon; Chiyi Xiong; Qian Huang; Andrew Elliott; Shaoli Song; Rui Zhang; Leo G. Flores; Juri G. Gelovani; Lihong V. Wang; Geng Ku; R. Jason Stafford; Chun Li

doi:10.1158/0008-5472.CAN-10-4557

Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma

Wei Lu, Marites P. Melancon, Chiyi Xiong, Qian Huang, Andrew Elliott, Shaoli Song, Rui Zhang, Leo G. Flores, Juri G. Gelovani, Lihong V. Wang, Geng Ku, R. Jason Stafford, Chun Li

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180 Scopus citations

Abstract

Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.

Original language	English (US)
Pages (from-to)	6116-6121
Number of pages	6
Journal	Cancer Research
Volume	71
Issue number	19
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-4557
State	Published - Oct 1 2011

ASJC Scopus subject areas

Oncology
Cancer Research

MD Anderson CCSG core facilities

High Resolution Electron Microscopy Facility
Cytogenetics and Cell Authentication Core

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Lu, W., Melancon, M. P., Xiong, C., Huang, Q., Elliott, A., Song, S., Zhang, R., Flores, L. G., Gelovani, J. G., Wang, L. V., Ku, G., Stafford, R. J., & Li, C. (2011). Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Research, 71(19), 6116-6121. https://doi.org/10.1158/0008-5472.CAN-10-4557

Lu, W, Melancon, MP , Xiong, C, Huang, Q, Elliott, A, Song, S, Zhang, R, Flores, LG, Gelovani, JG, Wang, LV, Ku, G, Stafford, RJ & Li, C 2011, 'Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma', Cancer Research, vol. 71, no. 19, pp. 6116-6121. https://doi.org/10.1158/0008-5472.CAN-10-4557

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abstract = "Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.",

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AU - Elliott, Andrew

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AU - Flores, Leo G.

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Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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