Effects of serotonin synthesis blockade on interleukin-1β action in the brain of rats

Olga E. Zubareva; Irina N. Krasnova; Irina N. Abdurasulova; Rose Marie Bluthe; Robert Dantzer; Victor M. Klimenko

doi:10.1016/S0006-8993(01)02910-9

Effects of serotonin synthesis blockade on interleukin-1β action in the brain of rats

Olga E. Zubareva, Irina N. Krasnova, Irina N. Abdurasulova, Rose Marie Bluthe, Robert Dantzer, Victor M. Klimenko

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The ability of the brain serotonergic system to mediate the effects of interleukin-1β (IL-1β) was investigated. Intracerebroventricular administration of IL-1β induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1β-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.

Original language	English (US)
Pages (from-to)	244-247
Number of pages	4
Journal	Brain Research
Volume	915
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02910-9
State	Published - Oct 12 2001
Externally published	Yes

Keywords

Body temperature
Body weight
Food intake
Interleukin-1β
Serotonin
Social behavior

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(01)02910-9

Cite this

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title = "Effects of serotonin synthesis blockade on interleukin-1β action in the brain of rats",

abstract = "The ability of the brain serotonergic system to mediate the effects of interleukin-1β (IL-1β) was investigated. Intracerebroventricular administration of IL-1β induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1β-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.",

keywords = "Body temperature, Body weight, Food intake, Interleukin-1β, Serotonin, Social behavior",

author = "Zubareva, {Olga E.} and Krasnova, {Irina N.} and Abdurasulova, {Irina N.} and Bluthe, {Rose Marie} and Robert Dantzer and Klimenko, {Victor M.}",

note = "Funding Information: The authors are very grateful to Dr. J.L. Cadet for editorial comments and remarks. This work was supported by RFBR (grant # 99-04-49511) and by the European Community Biomed Concerted action {\textquoteleft}Cytokines in the Brain{\textquoteright}.",

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T1 - Effects of serotonin synthesis blockade on interleukin-1β action in the brain of rats

AU - Zubareva, Olga E.

AU - Krasnova, Irina N.

AU - Abdurasulova, Irina N.

AU - Bluthe, Rose Marie

AU - Dantzer, Robert

AU - Klimenko, Victor M.

N1 - Funding Information: The authors are very grateful to Dr. J.L. Cadet for editorial comments and remarks. This work was supported by RFBR (grant # 99-04-49511) and by the European Community Biomed Concerted action ‘Cytokines in the Brain’.

PY - 2001/10/12

Y1 - 2001/10/12

N2 - The ability of the brain serotonergic system to mediate the effects of interleukin-1β (IL-1β) was investigated. Intracerebroventricular administration of IL-1β induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1β-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.

AB - The ability of the brain serotonergic system to mediate the effects of interleukin-1β (IL-1β) was investigated. Intracerebroventricular administration of IL-1β induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1β-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.

KW - Body temperature

KW - Body weight

KW - Food intake

KW - Interleukin-1β

KW - Serotonin

KW - Social behavior

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JF - Brain Research

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Effects of serotonin synthesis blockade on interleukin-1β action in the brain of rats

Abstract

Keywords

ASJC Scopus subject areas

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