TY - JOUR
T1 - Effects of social manipulations and environmental enrichment on behavior and cell-mediated immune responses in rhesus macaques
AU - Schapiro, Steven J.
N1 - Funding Information:
The work discussed in this article was conducted in collaboration with Drs. Mollie Bloomsmith, Jagan Sastry, Pramod Nehete, and Michale Keeling. Expert observational and technical support was provided by Jaine Perlman, Scott Suarez, Brock Boudreau, Amy Fultz, Madeline Rhodes, and Leila Porter. Thanks to the primate section staff for taking excellent care of the monkeys. Animals were maintained in facilities approved by the Association for Assessment and Accreditation for Laboratory Animal Care International and in accordance with current United States Department of Agriculture, Department of Health and Human Services, and National Institutes of Health regulations and standards. All experimental protocols were approved by the Institutional Animal Care and Use Committee of The University of Texas M. D. Anderson Cancer Center. Financial support for parts of the projects discussed came from the National Institutes of Health/NCRR grants U42-RR05080 (M.E. Keeling) and R01-RR05092 (M.A. Bloomsmith), the Biomedical Resources Foundation (S.J. Schapiro), NASA Cooperative Agreement NCC9-36 (K.J. Sastry), and Texas Higher Education Coordinating Board/ATP Award 15-014 (K.J. Sastry).
PY - 2002
Y1 - 2002
N2 - This paper reviews a series of studies that have examined the effects of manipulations to the social and the inanimate environments on the behavior and cell-mediated immune responses of rhesus macaques of various ages living in different settings. In general, enrichment of the inanimate environment with toys, structures, foraging devices, and/or videotapes increased the amount of species-typical behavior expressed by the monkeys, but did not affect their immune responses. Housing monkeys socially, on the other hand, not only resulted in increased time spent in species-typical activities, but also resulted in (1) decreases in time spent in abnormal behavior and (2) changes in a number of immune parameters. Additionally, attempts to directly influence the affiliative interactions of socially housed adult rhesus have resulted in systematic changes in affiliative behavior, although anticipated accompanying systematic alterations to cell-mediated immune responses have yet to be realized. The data suggest that aspects of the physical and social environments influence behavioral and immunological parameters in captive macaques in the absence of other experimental manipulations. As such, these influences need to be appropriately managed and/or controlled in order to minimize potential confounds in experimental designs.
AB - This paper reviews a series of studies that have examined the effects of manipulations to the social and the inanimate environments on the behavior and cell-mediated immune responses of rhesus macaques of various ages living in different settings. In general, enrichment of the inanimate environment with toys, structures, foraging devices, and/or videotapes increased the amount of species-typical behavior expressed by the monkeys, but did not affect their immune responses. Housing monkeys socially, on the other hand, not only resulted in increased time spent in species-typical activities, but also resulted in (1) decreases in time spent in abnormal behavior and (2) changes in a number of immune parameters. Additionally, attempts to directly influence the affiliative interactions of socially housed adult rhesus have resulted in systematic changes in affiliative behavior, although anticipated accompanying systematic alterations to cell-mediated immune responses have yet to be realized. The data suggest that aspects of the physical and social environments influence behavioral and immunological parameters in captive macaques in the absence of other experimental manipulations. As such, these influences need to be appropriately managed and/or controlled in order to minimize potential confounds in experimental designs.
KW - Behavior
KW - Cell-mediated immune responses
KW - Environmental enrichment
KW - Macaca mulatta
KW - Single housing
KW - Social housing
KW - Specific pathogen-free
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U2 - 10.1016/S0091-3057(02)00779-7
DO - 10.1016/S0091-3057(02)00779-7
M3 - Article
C2 - 12076745
AN - SCOPUS:0035985728
SN - 0091-3057
VL - 73
SP - 271
EP - 278
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 1
ER -