TY - JOUR
T1 - Effects of tamoxifen on cardiovascular risk factors in postmenopausal women
AU - Love, Richard R.
AU - Wiebe, Donald A.
AU - Newcomb, Polly A.
AU - Cameron, Linda
AU - Leventhal, Howard
AU - Jordan, V. Craig
AU - Feyzi, Jan
AU - DeMets, David L.
PY - 1991/12/1
Y1 - 1991/12/1
N2 - Objective: To determine the effects of tamoxifen on risk factors for cardiovascular disease in disease-free postmenopausal women. Design: Double-blind, placebo-controlled, randomized 2-year clinical trial. Setting: University health sciences center. ■ Patients: Clinically postmenopausal women (140) with a diagnosis of axillary node-negative breast cancer, who were disease-free by laboratory and clinical evaluations. Measurements: Levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B, glucose, weight, blood pressure, and reported exercise and work activity were measured. Main Results: Postmenopausal women receiving tamoxifen were evaluated at 3- or 6-month intervals during a 2-year assessment period and showed a mean decrease of 12% in total cholesterol levels (at 24 months - 0.672 mmol/L; 95% Cl, - 0.839 to - 0.505 mmol/L) and a mean decrease of 20% in calculated low-density lipoprotein (LDL) cholesterol levels (at 24 months, - 0.725 mmol/L; 95% Cl, - 0.868 to - 0.583 mmol/L) (P < 0.001). Women with greater baseline cholesterol levels had greater decreases with tamoxifen treatment. Levels of HDL cholesterol decreased in patients treated with tamoxifen, but this decrease was only statistically significant at one of five measurement times. Apolipoprotein A-I levels increased significantly at the two time points at which it was measured (P = 0.02), and apolipoprotein B levels decreased signifi-cantly at these times (P < 0.01) in patients treated with tamoxifen. Plasma glucose levels, reported exercise and work activity, reported smoking, weight, and systolic and diastolic blood pressures did not change with treatment. Conclusion: During 2 years of treatment, tamoxifen showed generally favorable effects on the lipid and lipoprotein profile of treated postmenopausal women. These effects may partially explain the decrease in adverse events and in mortality related to coronary heart disease seen in patients receiving adjuvant tamoxifen treatment.
AB - Objective: To determine the effects of tamoxifen on risk factors for cardiovascular disease in disease-free postmenopausal women. Design: Double-blind, placebo-controlled, randomized 2-year clinical trial. Setting: University health sciences center. ■ Patients: Clinically postmenopausal women (140) with a diagnosis of axillary node-negative breast cancer, who were disease-free by laboratory and clinical evaluations. Measurements: Levels of total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B, glucose, weight, blood pressure, and reported exercise and work activity were measured. Main Results: Postmenopausal women receiving tamoxifen were evaluated at 3- or 6-month intervals during a 2-year assessment period and showed a mean decrease of 12% in total cholesterol levels (at 24 months - 0.672 mmol/L; 95% Cl, - 0.839 to - 0.505 mmol/L) and a mean decrease of 20% in calculated low-density lipoprotein (LDL) cholesterol levels (at 24 months, - 0.725 mmol/L; 95% Cl, - 0.868 to - 0.583 mmol/L) (P < 0.001). Women with greater baseline cholesterol levels had greater decreases with tamoxifen treatment. Levels of HDL cholesterol decreased in patients treated with tamoxifen, but this decrease was only statistically significant at one of five measurement times. Apolipoprotein A-I levels increased significantly at the two time points at which it was measured (P = 0.02), and apolipoprotein B levels decreased signifi-cantly at these times (P < 0.01) in patients treated with tamoxifen. Plasma glucose levels, reported exercise and work activity, reported smoking, weight, and systolic and diastolic blood pressures did not change with treatment. Conclusion: During 2 years of treatment, tamoxifen showed generally favorable effects on the lipid and lipoprotein profile of treated postmenopausal women. These effects may partially explain the decrease in adverse events and in mortality related to coronary heart disease seen in patients receiving adjuvant tamoxifen treatment.
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U2 - 10.7326/0003-4819-115-11-860
DO - 10.7326/0003-4819-115-11-860
M3 - Article
C2 - 1952472
AN - SCOPUS:0025931791
SN - 0003-4819
VL - 115
SP - 860
EP - 864
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 11
ER -