TY - JOUR
T1 - Efficacy and Safety of Nedaplatin in Advanced Breast Cancer Therapy
AU - Pang, Hui
AU - Feng, Ting
AU - Lu, Hailing
AU - Meng, Qingwei
AU - Chen, Xuesong
AU - Shen, Qiang
AU - Dong, Xiaoqun
AU - Cai, Li
N1 - Funding Information:
This study was funded by National Natural Science Foundation of China (814021709), Chinese Postdoctoral Science Foundation (2012M510994), Heilongjiang Province Natural Science Fund (QC2012C012), Harbin Medical University Cancer Hospital Science Foundation (JJZ2011-16), The Education Department of Heilongjiang Province Overseas Scholars Sponsored Research Project (1254HQ015), National Natural Science Foundation of China (81172214), and Heilongjiang Province Natural Science Fund (LC2012C08).
Publisher Copyright:
© 2016 Taylor & Francis Group, LLC.
PY - 2016/4/20
Y1 - 2016/4/20
N2 - Purpose: To compare the time-to-treatment failure (TTF), overall survival (OS), overall response rate (ORR), and adverse effects of regimens including nedaplatin-or cisplatin-based chemotherapy for advanced breast cancer (ABC). Methods: A total of 171 patients with ABC (admission between July 2008 and July 2013) were retrospectively analyzed. Patients received either nedaplatin 75 mg/m2 (arm N; n = 85) or cisplatin 75 mg/m2 (arm C; n = 86) in combination with other second-generation chemotherapeutic drugs, such as paclitaxel 175 mg/m2, docetaxel 75 mg/m2, gemcitabine 1.25 g/m2, and navelbine 25 mg/m2 every 21 days (nedaplatin, cisplatin, paclitaxel, docetaxel on day 1; gemcitabine, navelbine on days 1 and 8). The primary endpoint was TTF in each arm; secondary endpoints were OS, ORR, and toxicity. Results: In the assessable patient population, in arm N, median TTF and OS was 13.87 months (95% CI: 11.55-16.19) and 31.53 months (95% CI: 28.42-34.64), respectively, with an ORR of 48.2%. In arm C, median TTF and OS was 8.7 months (95% CI: 5.82-11.59) and 24.87 months (95% CI: 18.98-30.75), respectively, with an ORR of 37.2%. The occurrence of grades 3 and 4 hematologic toxicity was more frequent (45.9% vs. 25.6%, p = 0.003) in arm N than in arm C. However, grade ≥2 nonhematologic toxicity was less frequent in arm N than in arm C (12.9% vs. 46.5%, p = 2.05 × 10-7). Conclusions: Nedaplatin-based chemotherapy regimen was well tolerated and efficiently improved patients' quality of life characterized by prolonged TTF and OS, with a marginal ORR.
AB - Purpose: To compare the time-to-treatment failure (TTF), overall survival (OS), overall response rate (ORR), and adverse effects of regimens including nedaplatin-or cisplatin-based chemotherapy for advanced breast cancer (ABC). Methods: A total of 171 patients with ABC (admission between July 2008 and July 2013) were retrospectively analyzed. Patients received either nedaplatin 75 mg/m2 (arm N; n = 85) or cisplatin 75 mg/m2 (arm C; n = 86) in combination with other second-generation chemotherapeutic drugs, such as paclitaxel 175 mg/m2, docetaxel 75 mg/m2, gemcitabine 1.25 g/m2, and navelbine 25 mg/m2 every 21 days (nedaplatin, cisplatin, paclitaxel, docetaxel on day 1; gemcitabine, navelbine on days 1 and 8). The primary endpoint was TTF in each arm; secondary endpoints were OS, ORR, and toxicity. Results: In the assessable patient population, in arm N, median TTF and OS was 13.87 months (95% CI: 11.55-16.19) and 31.53 months (95% CI: 28.42-34.64), respectively, with an ORR of 48.2%. In arm C, median TTF and OS was 8.7 months (95% CI: 5.82-11.59) and 24.87 months (95% CI: 18.98-30.75), respectively, with an ORR of 37.2%. The occurrence of grades 3 and 4 hematologic toxicity was more frequent (45.9% vs. 25.6%, p = 0.003) in arm N than in arm C. However, grade ≥2 nonhematologic toxicity was less frequent in arm N than in arm C (12.9% vs. 46.5%, p = 2.05 × 10-7). Conclusions: Nedaplatin-based chemotherapy regimen was well tolerated and efficiently improved patients' quality of life characterized by prolonged TTF and OS, with a marginal ORR.
KW - Breast cancer
KW - Chemotherapy
KW - Efficacy
KW - Nedaplatin
KW - Toxicity
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U2 - 10.3109/07357907.2016.1144061
DO - 10.3109/07357907.2016.1144061
M3 - Article
C2 - 27057601
AN - SCOPUS:84963999569
SN - 0735-7907
VL - 34
SP - 167
EP - 172
JO - Cancer Investigation
JF - Cancer Investigation
IS - 4
ER -