TY - JOUR
T1 - Efficacy and tolerability of micafungin monotherapy for candidemia and deep-seated candidiasis in adults with cancer
AU - Farmakiotis, Dimitrios
AU - Tarrand, Jeffrey J.
AU - Kontoyiannis, Dimitrios P.
PY - 2014/6
Y1 - 2014/6
N2 - The response rate among 58 patients with cancer and candidemia or deep-seated candidiasis treated with micafungin monotherapy was 81%. Intensive care unit (ICU) stay, concomitant nonfungal infections, and acute kidney injury were significantly associated with the 30-day crude mortality rate. Severe neutropenia was an independent predictor of micafungin failure. The efficacy and safety of micafungin in cancer patients with invasive candidiasis were comparable to those reported for patients without malignancy and for cancer patients treated with caspofungin.
AB - The response rate among 58 patients with cancer and candidemia or deep-seated candidiasis treated with micafungin monotherapy was 81%. Intensive care unit (ICU) stay, concomitant nonfungal infections, and acute kidney injury were significantly associated with the 30-day crude mortality rate. Severe neutropenia was an independent predictor of micafungin failure. The efficacy and safety of micafungin in cancer patients with invasive candidiasis were comparable to those reported for patients without malignancy and for cancer patients treated with caspofungin.
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UR - http://www.scopus.com/inward/citedby.url?scp=84901281345&partnerID=8YFLogxK
U2 - 10.1128/AAC.00051-14
DO - 10.1128/AAC.00051-14
M3 - Article
C2 - 24637687
AN - SCOPUS:84901281345
SN - 0066-4804
VL - 58
SP - 3526
EP - 3529
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 6
ER -